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Good CARMA: Turning bad tumor-resident myeloid cells good with chimeric antigen receptor macrophages
In religious philosophy, the concept of karma represents the effect of one's past and present actions on one's future. Macrophages are highly plastic cells with myriad roles in health and disease. In the setting of cancer, macrophages are among the most plentiful members of the immune micr...
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Published in: | Immunological reviews 2023-11, Vol.320 (1), p.236-249 |
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description | In religious philosophy, the concept of karma represents the effect of one's past and present actions on one's future. Macrophages are highly plastic cells with myriad roles in health and disease. In the setting of cancer, macrophages are among the most plentiful members of the immune microenvironment where they generally support tumor growth and restrain antitumor immunity. However, macrophages are not necessarily born bad. Macrophages or their immediate progenitors, monocytes, are induced to traffic to the tumor microenvironment (TME) and during this process they are polarized toward a tumor-promoting phenotype. Efforts to deplete or repolarize tumor-associated macrophages (TAM) for therapeutic benefit in cancer have to date disappointed. By contrast, genetic engineering of macrophages followed by their transit into the TME may allow these impressionable cells to mend their ways. In this review, we summarize and discuss recent advances in the genetic engineering of macrophages for the treatment of cancer. |
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Macrophages are highly plastic cells with myriad roles in health and disease. In the setting of cancer, macrophages are among the most plentiful members of the immune microenvironment where they generally support tumor growth and restrain antitumor immunity. However, macrophages are not necessarily born bad. Macrophages or their immediate progenitors, monocytes, are induced to traffic to the tumor microenvironment (TME) and during this process they are polarized toward a tumor-promoting phenotype. Efforts to deplete or repolarize tumor-associated macrophages (TAM) for therapeutic benefit in cancer have to date disappointed. By contrast, genetic engineering of macrophages followed by their transit into the TME may allow these impressionable cells to mend their ways. 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In this review, we summarize and discuss recent advances in the genetic engineering of macrophages for the treatment of cancer.</description><subject>Antigens</subject><subject>Cancer</subject><subject>Chimeric antigen receptors</subject><subject>Genetic engineering</subject><subject>Macrophages</subject><subject>Monocytes</subject><subject>Myeloid cells</subject><subject>Phenotypes</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><issn>0105-2896</issn><issn>1600-065X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LAzEQhoMotlYP_gEJeNHD1nzspllvpWgVKoJU8LZkk9k2pbupyS7Sf29qqwfnMpdnXt55ELqkZEjj3NnaDylnnB6hPhWEJERkH8eoTyjJEiZz0UNnIawIoSPO0lPU4yOWZ7lI-8hMnTN4Mn57Gd_jeecb2yxwqQxuu9r5xEOwBpoW11tYO2uwhvU64MXu6Mu2S6yXtgZvNVZNaxfQYA8aNq3zuFbau81SLSCco5NKrQNcHPYAvT8-zCdPyex1-jwZzxLNKW-TakSlESUIlgswJKcV00xKxbnSXEligAAwrQxolaVVSSESUIkyr0aaaM4H6Gafu_Hus4PQFrUNu8aqAdeFgkmWCikpoRG9_oeuXPw-totUnlKeMZlG6nZPxVdC8FAVG29r5bcFJcVOfRHVFz_qI3t1SOzKGswf-euafwPJhX_R</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Snyder, Christopher M</creator><creator>Gill, Saar I</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7946-7778</orcidid></search><sort><creationdate>20231101</creationdate><title>Good CARMA: Turning bad tumor-resident myeloid cells good with chimeric antigen receptor macrophages</title><author>Snyder, Christopher M ; Gill, Saar I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-f718d6be6296ed091f2c288a33ac3a80de0ee2cadeca54fb1e1f2ef6b9f7c0c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigens</topic><topic>Cancer</topic><topic>Chimeric antigen receptors</topic><topic>Genetic engineering</topic><topic>Macrophages</topic><topic>Monocytes</topic><topic>Myeloid cells</topic><topic>Phenotypes</topic><topic>Tumor microenvironment</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snyder, Christopher M</creatorcontrib><creatorcontrib>Gill, Saar I</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Immunological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snyder, Christopher M</au><au>Gill, Saar I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Good CARMA: Turning bad tumor-resident myeloid cells good with chimeric antigen receptor macrophages</atitle><jtitle>Immunological reviews</jtitle><addtitle>Immunol Rev</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>320</volume><issue>1</issue><spage>236</spage><epage>249</epage><pages>236-249</pages><issn>0105-2896</issn><eissn>1600-065X</eissn><abstract>In religious philosophy, the concept of karma represents the effect of one's past and present actions on one's future. 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subjects | Antigens Cancer Chimeric antigen receptors Genetic engineering Macrophages Monocytes Myeloid cells Phenotypes Tumor microenvironment Tumors |
title | Good CARMA: Turning bad tumor-resident myeloid cells good with chimeric antigen receptor macrophages |
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