Control of biomaterial-associated infections through biofabrication of gold nanoparticles using Musa sapientum extract

Biofilm-associated infections are a critical element in infectious diseases and play an important role in antibiotic resistance. Biosynthesized gold nanoparticles (AuNPs) using ethanolic extract of Musa sapientum unripe fruit were performed. The nanoparticles demonstrated an absorption peak at 554 n...

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Bibliographic Details
Published in:Biotechnology journal 2023-10, Vol.18 (10), p.e2300008-e2300008
Main Authors: Paosen, Supakit, Bilhman, Siwaporn, Wunnoo, Suttiwan, Ramanathan, Srinivasan, Septama, Abdi Wira, Lethongkam, Sakkarin, Voravuthikunchai, Supayang Piyawan
Format: Article
Language:English
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Summary:Biofilm-associated infections are a critical element in infectious diseases and play an important role in antibiotic resistance. Biosynthesized gold nanoparticles (AuNPs) using ethanolic extract of Musa sapientum unripe fruit were performed. The nanoparticles demonstrated an absorption peak at 554 nm with particle sizes ranging from 5.45 to 104.44 nm. High negative zeta potential value of -33.97 mV confirmed the high stability of AuNPs. The presence of bioconstituents responsible for capping and stabilization was indicated by intensity changes of several peaks from Fourier-transform infrared spectroscopy analysis. The minimum inhibitory concentrations (MIC) of the biosynthesized AuNPs against important pathogens ranged from 10 to 40 μg mL . Synthesized nanoparticles at 0.062 to 0.5 × MIC significantly inhibited biofilm formation in all the tested microorganisms (p 
ISSN:1860-6768
1860-7314
DOI:10.1002/biot.202300008