Natural TEMPO oxidized cellulose nano fiber/alginate/dSECM hybrid aerogel with improved wound healing and hemostatic ability

Natural biopolymers have attracted considerable attention in a variety of biomedical applications. Herein, tempo-oxidized-cellulose nanofibers (T) were incorporated into sodium alginate/chitosan (A/C) to reinforce the physicochemical properties and further modified with decellularized skin extracell...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-07, Vol.243, p.125226-125226, Article 125226
Main Authors: Tripathi, Garima, Park, Myeongki, Lim, Hansung, Lee, Byong-Taek
Format: Article
Language:English
Subjects:
Alginate
Chitosan
dSECM
TOCNF
Wound dressing
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Summary:Natural biopolymers have attracted considerable attention in a variety of biomedical applications. Herein, tempo-oxidized-cellulose nanofibers (T) were incorporated into sodium alginate/chitosan (A/C) to reinforce the physicochemical properties and further modified with decellularized skin extracellular matrix (E). A unique ACTE aerogel was successfully prepared, and its nontoxic behavior was validated using mouse fibroblast L929 cells. In vitro hemolysis results revealed excellent platelet adhesion and fibrin network formation abilities of the obtained aerogel. A high speed of homeostasis was attained based on the quick clotting in
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.125226