Polyketides from the fungus Pochonia chlamydosporia and their bioactivities

• Published in: Phytochemistry (Oxford) 2023-09, Vol.213, p.113747-113747, Article 113747
• Main Authors: Teng, Si-Qiong, Du, Jiao-Xian, Wang, Meng-Xi, Gao, Ming-Xuan, He, Juan, Yang, Yan-Ling, Liu, Ji-Kai, Feng, Tao
• Format: Article
• Language: English
• Subjects: Antifungal activity; Candida albicans; Cytotoxicity; Griseofulvin; Humans; Hypocreales; MCF-7 Cells; Pochonia chlamydosporia; Polyketides; Polyketides - chemistry
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2023.113747

Three previously undescribed griseofulvin derivatives, namely pochonichlamydins A–C, one small polyketide, namely pochonichlamydin D, together with nine known compounds, have been isolated from cultures of the fungus Pochonia chlamydosporia. Their structures with absolute configurations were elucidated on the basis of extensive spectrometric methods and single-crystal X-ray diffraction. Dechlorogriseofulvin and griseofulvin exhibited inhibitory activities against Candida albicans at the concentration of 100 μM, with inhibition rates of 69.1% and 56.3%, respectively. Meanwhile, pochonichlamydin C showed mild cytotoxicity against the human cancer MCF-7 cell line with an IC50 value of 33.1 μM. Griseofulvin derivatives and other polyketides have been isolated from the fungus Pochonia chlamydosporia. Some of them exhibited antifungal activity or cytotoxicity. [Display omitted] •Five undescribed polyketides were isolated from Pochonia chlamydosporia.•Three structures were confirmed by X-ray diffraction.•Three compounds displayed anti-fungal or cytotoxic activities.