Are we reaching the maximum cure rate for Hodgkin lymphoma?

The treatment of Hodgkin lymphoma, using cytotoxic chemotherapy and selective radiotherapy, has resulted in progressively increasing cure rates over the last 40 years. Recent studies have been directed at using response‐adapted approaches to modulate treatment according to the responses seen using f...

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Bibliographic Details
Published in:Hematological oncology 2023-06, Vol.41 (S1), p.57-61
Main Author: Johnson, Peter W. M.
Format: Article
Language:English
Subjects:
antibody‐drug conjugate
checkpoint blocking antibody
chemotherapy
Composite Resins - therapeutic use
FDG‐PET
Hodgkin Disease - drug therapy
Hodgkin lymphoma
Humans
Immunoconjugates - therapeutic use
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Summary:The treatment of Hodgkin lymphoma, using cytotoxic chemotherapy and selective radiotherapy, has resulted in progressively increasing cure rates over the last 40 years. Recent studies have been directed at using response‐adapted approaches to modulate treatment according to the responses seen using functional imaging, with the aim of balancing the probability of cure against the toxicity of more extensive treatments, in particular the risks of infertility, second malignancy and cardiovascular disease. The results of these studies suggest that we have reached the limits of what might be expected from the conventional treatments, but the arrival of antibody‐based therapies, specifically antibody‐drug conjugates and immune checkpoint blocking antibodies, now holds out the prospect of further improvements. The next challenge will be to select those groups for whom they are most needed.
ISSN:0278-0232
1099-1069
DOI:10.1002/hon.3140