Radioembolization Planning With Dual-Isotope Acquisition of 166 Ho-Labeled Microparticles and 99m Tc-Mebrofenin

A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT imaging of the scout dose 166 Ho-microparticles before injecte...

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Bibliographic Details
Published in:Clinical nuclear medicine 2023-08, Vol.48 (8), p.719-721
Main Authors: Czibor, Sándor, Bibok, András, Horváthy, Dénes, Fábián, Krisztián, Györke, Tamás
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - radiotherapy
Embolization, Therapeutic
Humans
Isotopes
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - drug therapy
Liver Neoplasms - radiotherapy
Male
Tomography, Emission-Computed, Single-Photon - methods
Yttrium Radioisotopes - therapeutic use
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Summary:A 76-year-old man with hepatocellular carcinoma was referred for liver radioembolization. Given a prior left hemihepatectomy, it was clinically important to consider potentially irradiated healthy liver at planning. Thus, at the SPECT/CT imaging of the scout dose 166 Ho-microparticles before injected superselectively in the right hepatic artery, 99m Tc-mebrofenin was injected intravenously, and functional volumetry SPECT was performed simultaneously. Based on the 2 image sets, the nonirradiated healthy liver was calculated as 1589 mL (functional liver reserve of 85.5% on 99m Tc-mebrofenin SPECT). Posttreatment dosimetry calculations showed optimal normal tissue and tumor absorbed doses, and the patient is clinically well after 3 months.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000004732