Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study

Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur. We evaluated the clinical features and comorbidities of patients with BD and a history of asthma. In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical character...

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Bibliographic Details
Published in:Journal of psychiatric research 2023-08, Vol.164, p.8-14
Main Authors: Romo-Nava, Francisco, Blom, Thomas, Cuellar-Barboza, Alfredo B., Barrera, Francisco J., Miola, Alessandro, Mori, Nicole N., Prieto, Miguel L., Veldic, Marin, Singh, Balwinder, Gardea-Resendez, Manuel, Nunez, Nicolas A., Ozerdem, Aysegul, Biernacka, Joanna M., Frye, Mark A., McElroy, Susan L.
Format: Article
Language:English
Subjects:
Asthma
Bipolar disorder
Chronotype
Comorbid
Fibromyalgia
Hypertension
Lithium
Migraine
Osteoarthritis
Sleep apnea
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Summary:Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur. We evaluated the clinical features and comorbidities of patients with BD and a history of asthma. In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical characteristics of the BD and an asthma phenotype and fitted a multivariable regression model to identify risk factors for asthma. A total of 721 individuals with BD were included. From these, 140 (19%) had a history of asthma. In a multivariable model only sex and evening chronotype were significant predictors of asthma with the odds ratios and 95% confidence intervals being 1.65 (1.00, 2.72; p=0.05) and 1.99 (1.25, 3.17; p 
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2023.05.061