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Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study
Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur. We evaluated the clinical features and comorbidities of patients with BD and a history of asthma. In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical character...
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| Published in: | Journal of psychiatric research 2023-08, Vol.164, p.8-14 |
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| creator | Romo-Nava, Francisco Blom, Thomas Cuellar-Barboza, Alfredo B. Barrera, Francisco J. Miola, Alessandro Mori, Nicole N. Prieto, Miguel L. Veldic, Marin Singh, Balwinder Gardea-Resendez, Manuel Nunez, Nicolas A. Ozerdem, Aysegul Biernacka, Joanna M. Frye, Mark A. McElroy, Susan L. |
| description | Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur.
We evaluated the clinical features and comorbidities of patients with BD and a history of asthma.
In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical characteristics of the BD and an asthma phenotype and fitted a multivariable regression model to identify risk factors for asthma.
A total of 721 individuals with BD were included. From these, 140 (19%) had a history of asthma. In a multivariable model only sex and evening chronotype were significant predictors of asthma with the odds ratios and 95% confidence intervals being 1.65 (1.00, 2.72; p=0.05) and 1.99 (1.25, 3.17; p |
| doi_str_mv | 10.1016/j.jpsychires.2023.05.061 |
| format | article |
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We evaluated the clinical features and comorbidities of patients with BD and a history of asthma.
In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical characteristics of the BD and an asthma phenotype and fitted a multivariable regression model to identify risk factors for asthma.
A total of 721 individuals with BD were included. From these, 140 (19%) had a history of asthma. In a multivariable model only sex and evening chronotype were significant predictors of asthma with the odds ratios and 95% confidence intervals being 1.65 (1.00, 2.72; p=0.05) and 1.99 (1.25, 3.17; p < 0.01), respectively. Individuals with asthma had higher odds of having other medical comorbidities after adjusting for age, sex, and site including hypertension (OR = 2.29 (95% CI 1.42, 3.71); p < 0.01), fibromyalgia (2.29 (1.16, 4.51); p=0.02), obstructive sleep apnea (2.03 (1.18, 3.50); p=0.01), migraine (1.98 (1.31, 3.00); p < 0.01), osteoarthritis (2.08 (1.20, 3.61); p < 0.01), and COPD (2.80 (1.14, 6.84); p=0.02). Finally, individuals currently on lithium were less likely to have a history of asthma (0.48 (0.32, 0.71); p < 0.01).
A history of asthma is common among patients with BD and is associated with being female and having an evening chronotype, as well as with increased odds of having other medical comorbidities. A lower likelihood of a history of asthma among those currently on lithium is an intriguing finding with potential clinical implications that warrants further study.
•One in five patients (19%) with BD reported a history of asthma.•Being female and having an evening chronotype were associated with asthma.•Comorbidities with an inflammatory component were associated with asthma.•Patients treated with lithium were less likely to report a history of asthma.•The circadian and immune systems may be implicated in the BD and asthma phenotype.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2023.05.061</identifier><identifier>PMID: 37290273</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Asthma ; Bipolar disorder ; Chronotype ; Comorbid ; Fibromyalgia ; Hypertension ; Lithium ; Migraine ; Osteoarthritis ; Sleep apnea</subject><ispartof>Journal of psychiatric research, 2023-08, Vol.164, p.8-14</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-7aca6b0c49c895189f0908444595f1e7ff90654ede4c91b3c15c07b87ae96eac3</citedby><cites>FETCH-LOGICAL-c374t-7aca6b0c49c895189f0908444595f1e7ff90654ede4c91b3c15c07b87ae96eac3</cites><orcidid>0000-0001-7062-8192 ; 0000-0003-4210-0299 ; 0000-0001-5578-4605 ; 0000-0002-9825-8792 ; 0000-0002-5894-3701</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37290273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romo-Nava, Francisco</creatorcontrib><creatorcontrib>Blom, Thomas</creatorcontrib><creatorcontrib>Cuellar-Barboza, Alfredo B.</creatorcontrib><creatorcontrib>Barrera, Francisco J.</creatorcontrib><creatorcontrib>Miola, Alessandro</creatorcontrib><creatorcontrib>Mori, Nicole N.</creatorcontrib><creatorcontrib>Prieto, Miguel L.</creatorcontrib><creatorcontrib>Veldic, Marin</creatorcontrib><creatorcontrib>Singh, Balwinder</creatorcontrib><creatorcontrib>Gardea-Resendez, Manuel</creatorcontrib><creatorcontrib>Nunez, Nicolas A.</creatorcontrib><creatorcontrib>Ozerdem, Aysegul</creatorcontrib><creatorcontrib>Biernacka, Joanna M.</creatorcontrib><creatorcontrib>Frye, Mark A.</creatorcontrib><creatorcontrib>McElroy, Susan L.</creatorcontrib><title>Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur.
We evaluated the clinical features and comorbidities of patients with BD and a history of asthma.
In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical characteristics of the BD and an asthma phenotype and fitted a multivariable regression model to identify risk factors for asthma.
A total of 721 individuals with BD were included. From these, 140 (19%) had a history of asthma. In a multivariable model only sex and evening chronotype were significant predictors of asthma with the odds ratios and 95% confidence intervals being 1.65 (1.00, 2.72; p=0.05) and 1.99 (1.25, 3.17; p < 0.01), respectively. Individuals with asthma had higher odds of having other medical comorbidities after adjusting for age, sex, and site including hypertension (OR = 2.29 (95% CI 1.42, 3.71); p < 0.01), fibromyalgia (2.29 (1.16, 4.51); p=0.02), obstructive sleep apnea (2.03 (1.18, 3.50); p=0.01), migraine (1.98 (1.31, 3.00); p < 0.01), osteoarthritis (2.08 (1.20, 3.61); p < 0.01), and COPD (2.80 (1.14, 6.84); p=0.02). Finally, individuals currently on lithium were less likely to have a history of asthma (0.48 (0.32, 0.71); p < 0.01).
A history of asthma is common among patients with BD and is associated with being female and having an evening chronotype, as well as with increased odds of having other medical comorbidities. A lower likelihood of a history of asthma among those currently on lithium is an intriguing finding with potential clinical implications that warrants further study.
•One in five patients (19%) with BD reported a history of asthma.•Being female and having an evening chronotype were associated with asthma.•Comorbidities with an inflammatory component were associated with asthma.•Patients treated with lithium were less likely to report a history of asthma.•The circadian and immune systems may be implicated in the BD and asthma phenotype.</description><subject>Asthma</subject><subject>Bipolar disorder</subject><subject>Chronotype</subject><subject>Comorbid</subject><subject>Fibromyalgia</subject><subject>Hypertension</subject><subject>Lithium</subject><subject>Migraine</subject><subject>Osteoarthritis</subject><subject>Sleep apnea</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v2zAMhoVixZp2-wuFjrvYpWTJsnbrgn4BBXZZz4Is07ACx_IkZVv66-ss3XrsiQT4vCT4EEIZlAxYfbUpN3Pau8FHTCUHXpUgS6jZCVmxRumCVUp_ICsAzotKy_qMnKe0AQDFmfhIzirFNXBVrYhfj37yzo7UDTZalzH6Z5t9mGjo6bx0OOVEf_s80NbPYbSRdj6F2GGkduqopYNPOcT9gbcpD1v7lV5PFP_MY4j27yTlXbf_RE57Oyb8_FovyNPtzY_1ffH4_e5hff1YuEqJXCjrbN2CE9o1WrJG96ChEUJILXuGqu811FJgh8Jp1laOSQeqbZRFXaN11QX5ctw7x_BzhymbrU8Ox9FOGHbJ8IaLWkuQbEGbI-piSClib-botzbuDQNzEG025k20OYg2IM0ieolevl7ZtVvs_gf_mV2Ab0cAl19_eYwmucWlw27Z5bLpgn__ygsif5Z4</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Romo-Nava, Francisco</creator><creator>Blom, Thomas</creator><creator>Cuellar-Barboza, Alfredo B.</creator><creator>Barrera, Francisco J.</creator><creator>Miola, Alessandro</creator><creator>Mori, Nicole N.</creator><creator>Prieto, Miguel L.</creator><creator>Veldic, Marin</creator><creator>Singh, Balwinder</creator><creator>Gardea-Resendez, Manuel</creator><creator>Nunez, Nicolas A.</creator><creator>Ozerdem, Aysegul</creator><creator>Biernacka, Joanna M.</creator><creator>Frye, Mark A.</creator><creator>McElroy, Susan L.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7062-8192</orcidid><orcidid>https://orcid.org/0000-0003-4210-0299</orcidid><orcidid>https://orcid.org/0000-0001-5578-4605</orcidid><orcidid>https://orcid.org/0000-0002-9825-8792</orcidid><orcidid>https://orcid.org/0000-0002-5894-3701</orcidid></search><sort><creationdate>202308</creationdate><title>Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study</title><author>Romo-Nava, Francisco ; Blom, Thomas ; Cuellar-Barboza, Alfredo B. ; Barrera, Francisco J. ; Miola, Alessandro ; Mori, Nicole N. ; Prieto, Miguel L. ; Veldic, Marin ; Singh, Balwinder ; Gardea-Resendez, Manuel ; Nunez, Nicolas A. ; Ozerdem, Aysegul ; Biernacka, Joanna M. ; Frye, Mark A. ; McElroy, Susan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-7aca6b0c49c895189f0908444595f1e7ff90654ede4c91b3c15c07b87ae96eac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Asthma</topic><topic>Bipolar disorder</topic><topic>Chronotype</topic><topic>Comorbid</topic><topic>Fibromyalgia</topic><topic>Hypertension</topic><topic>Lithium</topic><topic>Migraine</topic><topic>Osteoarthritis</topic><topic>Sleep apnea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romo-Nava, Francisco</creatorcontrib><creatorcontrib>Blom, Thomas</creatorcontrib><creatorcontrib>Cuellar-Barboza, Alfredo B.</creatorcontrib><creatorcontrib>Barrera, Francisco J.</creatorcontrib><creatorcontrib>Miola, Alessandro</creatorcontrib><creatorcontrib>Mori, Nicole N.</creatorcontrib><creatorcontrib>Prieto, Miguel L.</creatorcontrib><creatorcontrib>Veldic, Marin</creatorcontrib><creatorcontrib>Singh, Balwinder</creatorcontrib><creatorcontrib>Gardea-Resendez, Manuel</creatorcontrib><creatorcontrib>Nunez, Nicolas A.</creatorcontrib><creatorcontrib>Ozerdem, Aysegul</creatorcontrib><creatorcontrib>Biernacka, Joanna M.</creatorcontrib><creatorcontrib>Frye, Mark A.</creatorcontrib><creatorcontrib>McElroy, Susan L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romo-Nava, Francisco</au><au>Blom, Thomas</au><au>Cuellar-Barboza, Alfredo B.</au><au>Barrera, Francisco J.</au><au>Miola, Alessandro</au><au>Mori, Nicole N.</au><au>Prieto, Miguel L.</au><au>Veldic, Marin</au><au>Singh, Balwinder</au><au>Gardea-Resendez, Manuel</au><au>Nunez, Nicolas A.</au><au>Ozerdem, Aysegul</au><au>Biernacka, Joanna M.</au><au>Frye, Mark A.</au><au>McElroy, Susan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2023-08</date><risdate>2023</risdate><volume>164</volume><spage>8</spage><epage>14</epage><pages>8-14</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Bipolar disorder (BD) and asthma are leading causes of morbidity in the US and frequently co-occur.
We evaluated the clinical features and comorbidities of patients with BD and a history of asthma.
In a cross-sectional analysis from the Mayo Clinic Bipolar Biobank, we explored the clinical characteristics of the BD and an asthma phenotype and fitted a multivariable regression model to identify risk factors for asthma.
A total of 721 individuals with BD were included. From these, 140 (19%) had a history of asthma. In a multivariable model only sex and evening chronotype were significant predictors of asthma with the odds ratios and 95% confidence intervals being 1.65 (1.00, 2.72; p=0.05) and 1.99 (1.25, 3.17; p < 0.01), respectively. Individuals with asthma had higher odds of having other medical comorbidities after adjusting for age, sex, and site including hypertension (OR = 2.29 (95% CI 1.42, 3.71); p < 0.01), fibromyalgia (2.29 (1.16, 4.51); p=0.02), obstructive sleep apnea (2.03 (1.18, 3.50); p=0.01), migraine (1.98 (1.31, 3.00); p < 0.01), osteoarthritis (2.08 (1.20, 3.61); p < 0.01), and COPD (2.80 (1.14, 6.84); p=0.02). Finally, individuals currently on lithium were less likely to have a history of asthma (0.48 (0.32, 0.71); p < 0.01).
A history of asthma is common among patients with BD and is associated with being female and having an evening chronotype, as well as with increased odds of having other medical comorbidities. A lower likelihood of a history of asthma among those currently on lithium is an intriguing finding with potential clinical implications that warrants further study.
•One in five patients (19%) with BD reported a history of asthma.•Being female and having an evening chronotype were associated with asthma.•Comorbidities with an inflammatory component were associated with asthma.•Patients treated with lithium were less likely to report a history of asthma.•The circadian and immune systems may be implicated in the BD and asthma phenotype.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37290273</pmid><doi>10.1016/j.jpsychires.2023.05.061</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7062-8192</orcidid><orcidid>https://orcid.org/0000-0003-4210-0299</orcidid><orcidid>https://orcid.org/0000-0001-5578-4605</orcidid><orcidid>https://orcid.org/0000-0002-9825-8792</orcidid><orcidid>https://orcid.org/0000-0002-5894-3701</orcidid></addata></record> |
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| subjects | Asthma Bipolar disorder Chronotype Comorbid Fibromyalgia Hypertension Lithium Migraine Osteoarthritis Sleep apnea |
| title | Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study |
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