Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy

Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. PVA/BA NPs were synthesized and intravenously inject...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2023-04, Vol.18 (9), p.743-754
Main Authors: Chan, Wei-Jen, Bupphathong, Sasinan, Cho, Han-Lin, Goudar, Venkanagouda S, Dehestani, Sina, Chiang, Chi-Shiun, Tseng, Fan-Gang
Format: Article
Language:English
Subjects:
Animals
BNCT
boric acid
Boron Neutron Capture Therapy - methods
Chemical Engineering
Disease Models, Animal
head and neck cancer
Male
Mice
Mouth Neoplasms - radiotherapy
Nanoparticles
poly(vinyl alcohol)
polymeric nanoparticles
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Summary:Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT. The boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model. PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2022-0330