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Inflammatory reaction in eyes with late in‐the‐bag intraocular lens dislocation
Purpose To investigate the inflammatory reaction in eyes with late in‐the‐bag intraocular lens (IOL) dislocation. Methods This prospective clinical study with fellow‐eye comparison consists of 76 of the patients (76 eyes) with late in‐the‐bag IOL dislocation enrolled in the LION trial. The main outc...
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Published in: | Acta ophthalmologica (Oxford, England) England), 2024-05, Vol.102 (3), p.306-311 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Purpose
To investigate the inflammatory reaction in eyes with late in‐the‐bag intraocular lens (IOL) dislocation.
Methods
This prospective clinical study with fellow‐eye comparison consists of 76 of the patients (76 eyes) with late in‐the‐bag IOL dislocation enrolled in the LION trial. The main outcome measure was anterior chamber flare before surgery measured with a laser flare meter in photon counts per millisecond (pc/ms). The dislocation was graded as 1 (small: optic still covering the visual axis), 2 (optic equator close to the visual axis) or 3 (optic decentred beyond the visual axis, but the IOL–capsule complex partly visible in the pupillary area). The secondary aim was to compare intraocular pressure (IOP) before surgery.
Results
Flare levels before surgery were significantly higher in the dislocation eyes than in the fellow eyes with a median flare of 21.5 (range 5.4–135.7) pc/ms versus 14.1 (2.0–42.9) pc/ms, respectively (p ˂ 0.001). A regression analysis of log‐transformed flare values showed that the dislocation eyes had a non‐significant tendency towards higher flare in dislocation grade 1 with a median flare of 24.6 (5.4–135.7) pc/ms compared to grade 2; 19.6 (6.5–41.5) pc/ms (p = 0.06), and no significant difference compared to grade 3; 19.4 (10.2–53.5) pc/ms (p = 0.47). The IOP was significantly higher in the dislocation eyes than in the fellow eyes (p ˂ 0.001).
Conclusions
Eyes with late in‐the‐bag IOL dislocation had increased flare levels compared to their fellow eyes. This suggests that inflammation is part of the clinical picture of late in‐the‐bag IOL dislocation. |
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ISSN: | 1755-375X 1755-3768 |
DOI: | 10.1111/aos.15720 |