Sphingolipid and Phospholipid Levels Are Altered in Human Brain in Chorea‐Acanthocytosis

Background Chorea‐acanthocytosis (ChAc) is associated with mutations of VPS13A, which encodes for chorein, a protein implicated in lipid transport at intracellular membrane contact sites. Objectives The goal of this study was to establish the lipidomic profile of patients with ChAc. Methods We analy...

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Bibliographic Details
Published in:Movement disorders 2023-08, Vol.38 (8), p.1535-1541
Main Authors: Miltenberger‐Miltenyi, Gabriel, Jones, Attila, Tetlow, Amber M., Conceição, Vasco A., Crary, John F., Ditzel, Ricky Michael, Farrell, Kurt, Nandakumar, Renu, Barton, Brandon, Karp, Barbara I., Kirby, Alana, Lett, Debra J., Mente, Karin, Morgello, Susan, Simon, David K., Walker, Ruth H.
Format: Article
Language:English
Subjects:
Animal models
Animals
brain
Brain - metabolism
Caudate nucleus
Chorea
chorea‐acanthocytosis
Humans
Lecithin
Lipids
Movement disorders
Neuroacanthocytosis - genetics
Neuroacanthocytosis - metabolism
Phosphatidylcholine
Phosphatidylserine
Phosphatidylserines - metabolism
Phospholipids
Phospholipids - metabolism
Prefrontal cortex
Protein transport
Putamen
sphingolipids
Sulfatide
Vesicular Transport Proteins - genetics
VPS13A
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Summary:Background Chorea‐acanthocytosis (ChAc) is associated with mutations of VPS13A, which encodes for chorein, a protein implicated in lipid transport at intracellular membrane contact sites. Objectives The goal of this study was to establish the lipidomic profile of patients with ChAc. Methods We analyzed 593 lipid species in the caudate nucleus (CN), putamen, and dorsolateral prefrontal cortex (DLPFC) from postmortem tissues of four patients with ChAc and six patients without ChAc. Results We found increased levels of bis(monoacylglycerol)phosphate, sulfatide, lysophosphatidylserine, and phosphatidylcholine ether in the CN and putamen, but not in the DLPFC, of patients with ChAc. Phosphatidylserine and monoacylglycerol were increased in the CN and N‐acyl phosphatidylserine in the putamen. N‐acyl serine was decreased in the CN and DLPFC, whereas lysophosphatidylinositol was decreased in the DLPFC. Conclusions We present the first evidence of altered sphingolipid and phospholipid levels in the brains of patients with ChAc. Our observations are congruent with recent findings in cellular and animal models, and implicate defects of lipid processing in VPS13A disease pathophysiology. © 2023 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.29445