Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes

The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemic...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2023-06, Vol.86 (6), p.1564-1570
Main Authors: Ozaki, Kaori, Asato, Yuka, Natsume, Noriyuki, Tojo, Shunya, Sumimoto, Shimpei, Iwasaki, Arihiro, Suenaga, Kiyotake, Teruya, Toshiaki
Format: Article
Language:English
Subjects:
Animals
Cyanobacteria - chemistry
Lipopeptides - chemistry
Marine Biology
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
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Summary:The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey’s analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.3c00256