Gemcitabine-associated digital necrosis in metastatic breast cancer

• Published in: Journal of oncology pharmacy practice 2023-10, Vol.29 (7), p.1770-1775
• Main Authors: Türkel, Alper, Özdemir, Mustafa, Kurtuluş, Aziz, Doğan, Mutlu
• Format: Article
• Language: English
• Subjects: Acetylsalicylic acid; Amputation; Angiography; Angioplasty; Balloon treatment; Breast cancer; Chemotherapy; Finger; Gemcitabine; Heparin; Ischemia; Malignancy; Medical treatment; Metastases; Metastasis; Molecular weight; Necrosis; Nucleoside analogs; Occlusion; Patients; Platinum compounds; Side effects; Thromboembolism; Thrombosis
• ISSN: 1078-1552; 1477-092X
• DOI: 10.1177/10781552231182356

Introduction Gemcitabine is a nucleoside analog antimetabolite used in various malignancies, including metastatic breast cancer. Objective response rates in its use as a single agent in the treatment of metastatic breast cancer are not to be underestimated. Cutaneous, hematological, pulmonary, and vascular side effects are well-known side effects. Venous thromboembolism may occur with antineoplastics, such as platinum compounds. Arterial thromboembolism is rare in cancer, almost rare with chemotherapy. Here, we present a metastatic breast cancer patient who had digital necrosis due to arterial occlusion with gemcitabine monotherapy. Case report A 54-year-old metastatic breast cancer female patient had digital ischemia and necrosis in the left hand's fifth finger after the second course of single-agent gemcitabine as the fourth line setting. Gemcitabine was discontinued, and medical treatment was started. Thrombus was detected in the left subclavian artery digital angiography. Balloon angioplasty and stenting were applied. However, digital amputation had to be performed since tissue necrosis had not regressed despite radiological interventions and medical treatment. Management and outcome Gemcitabine was discontinued. Low molecular weight heparin and acetylsalicylic acid were started. The distal phalanx was amputated due to necrosis during follow-up. Gemcitabine was permanently stopped. Discussion Gemcitabine-related vascular events, including arterial thrombosis, may also occur in cancer patients, especially those with higher tumor burden. Therefore, predisposing factors for hypercoagulability and vascular occlusion should be questioned in more detail even before starting antineoplastics which are known to have a lower risk for thrombosis, such as gemcitabine monotherapy.