Green Synthesis of Genistein‐Fortified Zinc Ferrite Nanoparticles as a Potent Hepatic Cancer Inhibitor: Validation through Experimental and Computational Studies

In hepatic cancer, precancerous nodules account for damage and inflammation in liver cells. Studies have proved that phyto‐compounds based on biosynthetic metallic nanoparticles display superior action against hepatic tumors. This study targeted the synthesis of genistein‐fortified zinc ferrite nano...

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Published in:Chemistry & biodiversity 2023-08, Vol.20 (8), p.e202300719-n/a
Main Authors: Otuechere, Chiagoziem A., Neupane, Netra P., Adewuyi, Adewale, Pathak, Prateek, Novak, Jurica, Grishina, Maria, Khalilullah, Habibullah, Jaremko, Mariusz, Verma, Amita
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Biochemical markers
Cancer
Cytotoxicity
Diethylnitrosamine
Genistein
Hepatocytes
human matrix metalloproteinase
Liver
Liver cancer
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
molecular dynamics
Nanoparticles
Nodules
Nucleation
Reducing agents
Scanning electron microscopy
Spectrophotometry
Synthesis
Tumors
zinc ferrite nanoparticles
Zinc ferrites
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Summary:In hepatic cancer, precancerous nodules account for damage and inflammation in liver cells. Studies have proved that phyto‐compounds based on biosynthetic metallic nanoparticles display superior action against hepatic tumors. This study targeted the synthesis of genistein‐fortified zinc ferrite nanoparticles (GENP) trailed by anticancer activity assessment against diethylnitrosamine and N‐acetyl‐2‐aminofluorene induced hepatic cancer. The process of nucleation was confirmed by UV/VIS spectrophotometry, X‐ray beam diffraction, field‐emission scanning electron microscopy, and FT‐IR. An in vitro antioxidant assay illustrated that the leaves of Pterocarpus mildbraedii have strong tendency as a reductant and, in the nanoformulation synthesis, as a natural capping agent. A MTT assay confirmed that GENP have a strong selective cytotoxic potential against HepG2 cancer cells. In silico studies of genistein exemplified the binding tendency towards human matrix metalloproteinase comparative to the standard drug marimastat. An in vivo anticancer evaluation showed that GENP effectively inhibit the growth of hepatic cancer by interfering with hepatic and non‐hepatic biochemical markers.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300719