Ni-Catalyzed Protecting Group Free Diphenic Acid Analog Synthesis

Severe side effects and drug resistance are major drawbacks of Pt-based chemotherapy in clinical practice, leading to the search for new Pt-based drugs through the tuning of coordination ligands. Therefore, seeking appropriate ligands has attracted significant interest in this area. In this study, w...

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Bibliographic Details
Published in:Organic letters 2023-06, Vol.25 (25), p.4700-4704
Main Authors: Zhao, Bo-Wei, Yang, Liu, Long, Cheng-Yu, Li, Han-Lu, He, Yu-Ting, Wang, Xue-Qiang
Format: Article
Language:English
Subjects:
Biphenyl Compounds
Catalysis
Ligands
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Summary:Severe side effects and drug resistance are major drawbacks of Pt-based chemotherapy in clinical practice, leading to the search for new Pt-based drugs through the tuning of coordination ligands. Therefore, seeking appropriate ligands has attracted significant interest in this area. In this study, we report a Ni-catalyzed coupling strategy for the divergent synthesis of diphenic acid derivatives and the application of these newly prepared acids in Pt­(II) agent synthesis.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c01625