Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts

Retrograde menstruation is a widely accepted cause of endometriosis. However, not all women who experience retrograde menstruation develop endometriosis, and the mechanisms underlying these observations are not yet understood. Here, we demonstrated a pathogenic role of in the formation of ovarian en...

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Published in:Science translational medicine 2023-06, Vol.15 (700), p.eadd1531-eadd1531
Main Authors: Muraoka, Ayako, Suzuki, Miho, Hamaguchi, Tomonari, Watanabe, Shinya, Iijima, Kenta, Murofushi, Yoshiteru, Shinjo, Keiko, Osuka, Satoko, Hariyama, Yumi, Ito, Mikako, Ohno, Kinji, Kiyono, Tohru, Kyo, Satoru, Iwase, Akira, Kikkawa, Fumitaka, Kajiyama, Hiroaki, Kondo, Yutaka
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Endometriosis
Endometrium
Female
Fibroblasts
Fusobacterium
Fusobacterium Infections
Humans
Infections
Inoculation
Menstruation
Mice
Myofibroblasts
Transforming growth factor-b
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Summary:Retrograde menstruation is a widely accepted cause of endometriosis. However, not all women who experience retrograde menstruation develop endometriosis, and the mechanisms underlying these observations are not yet understood. Here, we demonstrated a pathogenic role of in the formation of ovarian endometriosis. In a cohort of women, 64% of patients with endometriosis but
ISSN:1946-6234
1946-6242
1946-3242
DOI:10.1126/scitranslmed.add1531