Dysfunction of the intestinal physical barrier in the intestinal inflammation of tongue sole, Cynoglossus semilaevis, induced by Shewanella algae infection

Bacterial intestinal inflammation occurs frequently in cultured fish. However, research on the dysfunction of the intestinal physical barrier in fish intestinal inflammation is scarce. In this study, intestinal inflammation in tongue sole Cynoglossus semilaevis was induced by Shewanella algae and th...

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Bibliographic Details
Published in:Fish & shellfish immunology 2023-08, Vol.139, p.108900-108900, Article 108900
Main Authors: Han, Zhuoran, Ge, Lunhua, Wen, Siyi, Sun, Jingfeng
Format: Article
Language:English
Subjects:
Animals
Cynoglossus semilaevis
In Situ Hybridization, Fluorescence
Inflammation - metabolism
Intestinal inflammation
Intestinal Mucosa - metabolism
Intestinal permeability
Intestines
Keratins
RNA, Messenger - metabolism
Shewanella algae
Tight junctions
Tight Junctions - metabolism
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Summary:Bacterial intestinal inflammation occurs frequently in cultured fish. However, research on the dysfunction of the intestinal physical barrier in fish intestinal inflammation is scarce. In this study, intestinal inflammation in tongue sole Cynoglossus semilaevis was induced by Shewanella algae and the intestinal permeability was investigated. Gene expression patterns in inflammatory factors, tight junction molecules, and keratins 8 and 18 in the intestines were further explored. Histological examinations of the middle intestines showed that S. algae induced pathological lesions of intestinal inflammation and significantly increased the total number of mucous cells (p 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2023.108900