Alginate/chitosan hydrogels as perspective transport systems for cefotaxime

This work reports synthesis of pH-responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefot...

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Bibliographic Details
Published in:Biopolymers 2023-10, Vol.114 (10), p.e23555-e23555
Main Authors: Shilova, Svetlana V, Mirgaleev, Grigory M, Romanova, Ksenia A, Galyametdinov, Yury G
Format: Article
Language:English
Subjects:
Alginates
Alginic acid
Antibiotics
Aqueous solutions
Cefotaxime
Chitosan
Complexation
Composition
Hydrogels
Infrared spectroscopy
pH effects
Quantum chemistry
Spectrum analysis
Stability constants
Transportation systems
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Summary:This work reports synthesis of pH-responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH-dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer-Peppas model revealed a non-Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime-chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan-cefotaxime complexation considering the influence of a solvent.
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.23555