Mikania micrantha extract enhances cutaneous wound healing activity through the activation of FAK/Akt/mTOR cell signaling pathway

•Mikania micrantha extract (MME) induced proliferation of human dermal fibroblast.•MME enhances the invasion of endothelial cells and angiogenesis.•Topical application of MME increased wound contraction.•MME improved remodeling of the healing skin.•MME can potentially accelerate cutaneous wound heal...

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Bibliographic Details
Published in:Injury 2023-08, Vol.54 (8), p.110856-110856, Article 110856
Main Authors: Das, Gunjan, Farhan, Mohammad, Sinha, Sonam, Bora, Himangsu K., Singh, Wangkheirakpam Ramdas, Meeran, Syed Musthapa
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Endothelial Cells - metabolism
Fibroblast
Humans
Mikania - metabolism
Mikania micrantha
Plant Extracts - pharmacology
Proto-Oncogene Proteins c-akt - metabolism
Proto-Oncogene Proteins c-akt - pharmacology
Rats
Rats, Wistar
Signal Transduction
Skin
Skin remodeling
TOR Serine-Threonine Kinases - metabolism
TOR Serine-Threonine Kinases - pharmacology
Wound contraction
Wound healing
Wound Healing - physiology
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Summary:•Mikania micrantha extract (MME) induced proliferation of human dermal fibroblast.•MME enhances the invasion of endothelial cells and angiogenesis.•Topical application of MME increased wound contraction.•MME improved remodeling of the healing skin.•MME can potentially accelerate cutaneous wound healing. Mikania micrantha (MM) has been traditionally used for various health benefits, including mental health, anti-inflammatory, wound dressing, and healing of sores. However, the molecular mechanisms and dose required for the wound healing activity of MM have yet to be reported. Therefore, a study was conducted to evaluate the wound healing potential of a cold methanolic extract of MM through in vitro and in vivo studies. Human dermal fibroblast adult (HDFa) cells were treated with 0 (control), 75 ng/ml, 125 ng/ml, 250 ng/ml, and 500 ng/ml of MMmethanolic extract (MME) for 24 h. MME at 75 ng/ml has significantly (p˂0.05) promoted HDFa cell proliferation and migration. Further, MME has also been shown to enhance the invasiveness of human umbilical vascular endothelial cells (HUVECs), indicating the neovasculature for wound healing. The tube formation assay demonstrated a significant (p
ISSN:0020-1383
1879-0267
DOI:10.1016/j.injury.2023.110856