Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study

Background Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned. Objective The aim of this study was to...

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Bibliographic Details
Published in:Drugs & aging 2023-08, Vol.40 (8), p.731-739
Main Authors: Ohori, Katsuhiko, Yano, Toshiyuki, Katano, Satoshi, Nagaoka, Ryohei, Numazawa, Ryo, Yamano, Kotaro, Fujisawa, Yusuke, Kouzu, Hidemichi, Koyama, Masayuki, Nagano, Nobutaka, Fujito, Takefumi, Nishikawa, Ryo, Ohwada, Wataru, Furuhashi, Masato
Format: Article
Language:English
Subjects:
Body composition
Bone density
Cardiovascular disease
Geriatrics/Gerontology
Heart failure
Hospitals
Internal Medicine
Medicine
Medicine & Public Health
Musculoskeletal system
Nutritional status
Observational studies
Original Research Article
Pharmacology/Toxicology
Pharmacotherapy
Sarcopenia
Ulcers
Young adults
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Summary:Background Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned. Objective The aim of this study was to determine the effects of use of PPIs on muscle mass and bone mineral density in heart failure (HF) patients. Methods This was a single-center, ambispective (combined retrospective and prospective), observational study. HF patients ( n  = 747; 72 years of age; males, 54%) who received a dual-energy x-ray absorptiometry scan were enrolled. Muscle wasting was defined as appendicular skeletal muscle mass index (ASMI) < 7.0 kg/m 2 in males and
ISSN:1170-229X
1179-1969
DOI:10.1007/s40266-023-01035-3