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Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study
Background Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned. Objective The aim of this study was to...
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| Published in: | Drugs & aging 2023-08, Vol.40 (8), p.731-739 |
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| creator | Ohori, Katsuhiko Yano, Toshiyuki Katano, Satoshi Nagaoka, Ryohei Numazawa, Ryo Yamano, Kotaro Fujisawa, Yusuke Kouzu, Hidemichi Koyama, Masayuki Nagano, Nobutaka Fujito, Takefumi Nishikawa, Ryo Ohwada, Wataru Furuhashi, Masato |
| description | Background
Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned.
Objective
The aim of this study was to determine the effects of use of PPIs on muscle mass and bone mineral density in heart failure (HF) patients.
Methods
This was a single-center, ambispective (combined retrospective and prospective), observational study. HF patients (
n
= 747; 72 years of age; males, 54%) who received a dual-energy x-ray absorptiometry scan were enrolled. Muscle wasting was defined as appendicular skeletal muscle mass index (ASMI) < 7.0 kg/m
2
in males and |
| doi_str_mv | 10.1007/s40266-023-01035-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2827259595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2845719603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-889332a34ddc4eb13f4d7d98f6b0aaf2e6a669aa57977acda82199d6aa8504433</originalsourceid><addsrcrecordid>eNp9kc9u1DAQhyMEoqXwAhyQJS4cGvCfxI65LStKVypqpVLBLZrEk9ZVNkk9Tqs-T1-03t0CEgdkyR7Z3_w80pdlbwX_KDg3n6jgUuucS5VzwVWZq2fZvhDG5sJq-3xb81xK-2sve0V0zTnXUoqX2Z4ySlbaiP3sYTU4nDBtQ2QLorH1EP04sC8Y7xAHdkHIxo6dhTGm27N5PbHVcOUbH8dADAbHvs_U9sh-AkU_XDKfqBSR8ojd-XjFjhFCZEfg-zngZ7Zg5wnrMV8mBMMhW6wbTxO20d_iITttCMPtdgbo2Xmc3f3r7EUHPeGbp_Mguzj6-mN5nJ-cflstFyd5q0wZ86qySklQhXNtgY1QXeGMs1WnGw7QSdSgtQUojTUGWgeVFNY6DVCVvCiUOsg-7HKnMN7MSLFee2qx72HAcaZaVtLI0qaV0Pf_oNfjHNLEG6ooTRLAN4FyR7VhJArY1VPwawj3teD1RmG9U1gnhfVWYb1pevcUPTdrdH9afjtLgNoBlJ6GSwx___5P7COmOah1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2845719603</pqid></control><display><type>article</type><title>Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study</title><source>LexisNexis - News & Business</source><source>Springer Nature</source><creator>Ohori, Katsuhiko ; Yano, Toshiyuki ; Katano, Satoshi ; Nagaoka, Ryohei ; Numazawa, Ryo ; Yamano, Kotaro ; Fujisawa, Yusuke ; Kouzu, Hidemichi ; Koyama, Masayuki ; Nagano, Nobutaka ; Fujito, Takefumi ; Nishikawa, Ryo ; Ohwada, Wataru ; Furuhashi, Masato</creator><creatorcontrib>Ohori, Katsuhiko ; Yano, Toshiyuki ; Katano, Satoshi ; Nagaoka, Ryohei ; Numazawa, Ryo ; Yamano, Kotaro ; Fujisawa, Yusuke ; Kouzu, Hidemichi ; Koyama, Masayuki ; Nagano, Nobutaka ; Fujito, Takefumi ; Nishikawa, Ryo ; Ohwada, Wataru ; Furuhashi, Masato</creatorcontrib><description>Background
Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned.
Objective
The aim of this study was to determine the effects of use of PPIs on muscle mass and bone mineral density in heart failure (HF) patients.
Methods
This was a single-center, ambispective (combined retrospective and prospective), observational study. HF patients (
n
= 747; 72 years of age; males, 54%) who received a dual-energy x-ray absorptiometry scan were enrolled. Muscle wasting was defined as appendicular skeletal muscle mass index (ASMI) < 7.0 kg/m
2
in males and <5.4 kg/m
2
in females. Propensity scores for the use of PPIs were calculated using a multivariate logistic regression model to minimize selection bias.
Results
Before propensity score matching, ASMI was significantly lower in patients receiving PPIs than in patients not receiving PPIs, resulting in a higher prevalence of muscle wasting in the PPI group. Such a relationship between use of PPIs and muscle wasting remained after propensity score matching. In multivariate Cox regression analyses, use of PPIs was independently associated with presence of muscle wasting (hazard ratio 1.68, 95% confidence interval 1.05–2.69) after adjustment for established risk factors of sarcopenia. On the other hand, there were no differences in bone mineral density between the PPI group and the no-PPI group.
Conclusion
Use of PPIs is associated with a high risk of muscle wasting in HF patients. Caution is warranted when long-term PPI treatment is performed in sarcopenic HF patients and HF patients with several risk factors for muscle wasting.</description><identifier>ISSN: 1170-229X</identifier><identifier>EISSN: 1179-1969</identifier><identifier>DOI: 10.1007/s40266-023-01035-3</identifier><identifier>PMID: 37328671</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Body composition ; Bone density ; Cardiovascular disease ; Geriatrics/Gerontology ; Heart failure ; Hospitals ; Internal Medicine ; Medicine ; Medicine & Public Health ; Musculoskeletal system ; Nutritional status ; Observational studies ; Original Research Article ; Pharmacology/Toxicology ; Pharmacotherapy ; Sarcopenia ; Ulcers ; Young adults</subject><ispartof>Drugs & aging, 2023-08, Vol.40 (8), p.731-739</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><rights>Copyright Springer Nature B.V. Aug 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-889332a34ddc4eb13f4d7d98f6b0aaf2e6a669aa57977acda82199d6aa8504433</citedby><cites>FETCH-LOGICAL-c375t-889332a34ddc4eb13f4d7d98f6b0aaf2e6a669aa57977acda82199d6aa8504433</cites><orcidid>0000-0001-9655-3985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37328671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohori, Katsuhiko</creatorcontrib><creatorcontrib>Yano, Toshiyuki</creatorcontrib><creatorcontrib>Katano, Satoshi</creatorcontrib><creatorcontrib>Nagaoka, Ryohei</creatorcontrib><creatorcontrib>Numazawa, Ryo</creatorcontrib><creatorcontrib>Yamano, Kotaro</creatorcontrib><creatorcontrib>Fujisawa, Yusuke</creatorcontrib><creatorcontrib>Kouzu, Hidemichi</creatorcontrib><creatorcontrib>Koyama, Masayuki</creatorcontrib><creatorcontrib>Nagano, Nobutaka</creatorcontrib><creatorcontrib>Fujito, Takefumi</creatorcontrib><creatorcontrib>Nishikawa, Ryo</creatorcontrib><creatorcontrib>Ohwada, Wataru</creatorcontrib><creatorcontrib>Furuhashi, Masato</creatorcontrib><title>Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study</title><title>Drugs & aging</title><addtitle>Drugs Aging</addtitle><addtitle>Drugs Aging</addtitle><description>Background
Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned.
Objective
The aim of this study was to determine the effects of use of PPIs on muscle mass and bone mineral density in heart failure (HF) patients.
Methods
This was a single-center, ambispective (combined retrospective and prospective), observational study. HF patients (
n
= 747; 72 years of age; males, 54%) who received a dual-energy x-ray absorptiometry scan were enrolled. Muscle wasting was defined as appendicular skeletal muscle mass index (ASMI) < 7.0 kg/m
2
in males and <5.4 kg/m
2
in females. Propensity scores for the use of PPIs were calculated using a multivariate logistic regression model to minimize selection bias.
Results
Before propensity score matching, ASMI was significantly lower in patients receiving PPIs than in patients not receiving PPIs, resulting in a higher prevalence of muscle wasting in the PPI group. Such a relationship between use of PPIs and muscle wasting remained after propensity score matching. In multivariate Cox regression analyses, use of PPIs was independently associated with presence of muscle wasting (hazard ratio 1.68, 95% confidence interval 1.05–2.69) after adjustment for established risk factors of sarcopenia. On the other hand, there were no differences in bone mineral density between the PPI group and the no-PPI group.
Conclusion
Use of PPIs is associated with a high risk of muscle wasting in HF patients. Caution is warranted when long-term PPI treatment is performed in sarcopenic HF patients and HF patients with several risk factors for muscle wasting.</description><subject>Body composition</subject><subject>Bone density</subject><subject>Cardiovascular disease</subject><subject>Geriatrics/Gerontology</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Musculoskeletal system</subject><subject>Nutritional status</subject><subject>Observational studies</subject><subject>Original Research Article</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacotherapy</subject><subject>Sarcopenia</subject><subject>Ulcers</subject><subject>Young adults</subject><issn>1170-229X</issn><issn>1179-1969</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQhyMEoqXwAhyQJS4cGvCfxI65LStKVypqpVLBLZrEk9ZVNkk9Tqs-T1-03t0CEgdkyR7Z3_w80pdlbwX_KDg3n6jgUuucS5VzwVWZq2fZvhDG5sJq-3xb81xK-2sve0V0zTnXUoqX2Z4ySlbaiP3sYTU4nDBtQ2QLorH1EP04sC8Y7xAHdkHIxo6dhTGm27N5PbHVcOUbH8dADAbHvs_U9sh-AkU_XDKfqBSR8ojd-XjFjhFCZEfg-zngZ7Zg5wnrMV8mBMMhW6wbTxO20d_iITttCMPtdgbo2Xmc3f3r7EUHPeGbp_Mguzj6-mN5nJ-cflstFyd5q0wZ86qySklQhXNtgY1QXeGMs1WnGw7QSdSgtQUojTUGWgeVFNY6DVCVvCiUOsg-7HKnMN7MSLFee2qx72HAcaZaVtLI0qaV0Pf_oNfjHNLEG6ooTRLAN4FyR7VhJArY1VPwawj3teD1RmG9U1gnhfVWYb1pevcUPTdrdH9afjtLgNoBlJ6GSwx___5P7COmOah1</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Ohori, Katsuhiko</creator><creator>Yano, Toshiyuki</creator><creator>Katano, Satoshi</creator><creator>Nagaoka, Ryohei</creator><creator>Numazawa, Ryo</creator><creator>Yamano, Kotaro</creator><creator>Fujisawa, Yusuke</creator><creator>Kouzu, Hidemichi</creator><creator>Koyama, Masayuki</creator><creator>Nagano, Nobutaka</creator><creator>Fujito, Takefumi</creator><creator>Nishikawa, Ryo</creator><creator>Ohwada, Wataru</creator><creator>Furuhashi, Masato</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9655-3985</orcidid></search><sort><creationdate>20230801</creationdate><title>Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study</title><author>Ohori, Katsuhiko ; Yano, Toshiyuki ; Katano, Satoshi ; Nagaoka, Ryohei ; Numazawa, Ryo ; Yamano, Kotaro ; Fujisawa, Yusuke ; Kouzu, Hidemichi ; Koyama, Masayuki ; Nagano, Nobutaka ; Fujito, Takefumi ; Nishikawa, Ryo ; Ohwada, Wataru ; Furuhashi, Masato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-889332a34ddc4eb13f4d7d98f6b0aaf2e6a669aa57977acda82199d6aa8504433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body composition</topic><topic>Bone density</topic><topic>Cardiovascular disease</topic><topic>Geriatrics/Gerontology</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Musculoskeletal system</topic><topic>Nutritional status</topic><topic>Observational studies</topic><topic>Original Research Article</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacotherapy</topic><topic>Sarcopenia</topic><topic>Ulcers</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohori, Katsuhiko</creatorcontrib><creatorcontrib>Yano, Toshiyuki</creatorcontrib><creatorcontrib>Katano, Satoshi</creatorcontrib><creatorcontrib>Nagaoka, Ryohei</creatorcontrib><creatorcontrib>Numazawa, Ryo</creatorcontrib><creatorcontrib>Yamano, Kotaro</creatorcontrib><creatorcontrib>Fujisawa, Yusuke</creatorcontrib><creatorcontrib>Kouzu, Hidemichi</creatorcontrib><creatorcontrib>Koyama, Masayuki</creatorcontrib><creatorcontrib>Nagano, Nobutaka</creatorcontrib><creatorcontrib>Fujito, Takefumi</creatorcontrib><creatorcontrib>Nishikawa, Ryo</creatorcontrib><creatorcontrib>Ohwada, Wataru</creatorcontrib><creatorcontrib>Furuhashi, Masato</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Drugs & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohori, Katsuhiko</au><au>Yano, Toshiyuki</au><au>Katano, Satoshi</au><au>Nagaoka, Ryohei</au><au>Numazawa, Ryo</au><au>Yamano, Kotaro</au><au>Fujisawa, Yusuke</au><au>Kouzu, Hidemichi</au><au>Koyama, Masayuki</au><au>Nagano, Nobutaka</au><au>Fujito, Takefumi</au><au>Nishikawa, Ryo</au><au>Ohwada, Wataru</au><au>Furuhashi, Masato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study</atitle><jtitle>Drugs & aging</jtitle><stitle>Drugs Aging</stitle><addtitle>Drugs Aging</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>40</volume><issue>8</issue><spage>731</spage><epage>739</epage><pages>731-739</pages><issn>1170-229X</issn><eissn>1179-1969</eissn><abstract>Background
Although proton pump inhibitors (PPIs) play a pivotal role in the prevention and treatment of gastric acid-related diseases and gastrointestinal adverse events caused by antiplatelet therapies, the safety of long-term use of PPIs has been questioned.
Objective
The aim of this study was to determine the effects of use of PPIs on muscle mass and bone mineral density in heart failure (HF) patients.
Methods
This was a single-center, ambispective (combined retrospective and prospective), observational study. HF patients (
n
= 747; 72 years of age; males, 54%) who received a dual-energy x-ray absorptiometry scan were enrolled. Muscle wasting was defined as appendicular skeletal muscle mass index (ASMI) < 7.0 kg/m
2
in males and <5.4 kg/m
2
in females. Propensity scores for the use of PPIs were calculated using a multivariate logistic regression model to minimize selection bias.
Results
Before propensity score matching, ASMI was significantly lower in patients receiving PPIs than in patients not receiving PPIs, resulting in a higher prevalence of muscle wasting in the PPI group. Such a relationship between use of PPIs and muscle wasting remained after propensity score matching. In multivariate Cox regression analyses, use of PPIs was independently associated with presence of muscle wasting (hazard ratio 1.68, 95% confidence interval 1.05–2.69) after adjustment for established risk factors of sarcopenia. On the other hand, there were no differences in bone mineral density between the PPI group and the no-PPI group.
Conclusion
Use of PPIs is associated with a high risk of muscle wasting in HF patients. Caution is warranted when long-term PPI treatment is performed in sarcopenic HF patients and HF patients with several risk factors for muscle wasting.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37328671</pmid><doi>10.1007/s40266-023-01035-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9655-3985</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1170-229X |
| ispartof | Drugs & aging, 2023-08, Vol.40 (8), p.731-739 |
| issn | 1170-229X 1179-1969 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2827259595 |
| source | LexisNexis - News & Business; Springer Nature |
| subjects | Body composition Bone density Cardiovascular disease Geriatrics/Gerontology Heart failure Hospitals Internal Medicine Medicine Medicine & Public Health Musculoskeletal system Nutritional status Observational studies Original Research Article Pharmacology/Toxicology Pharmacotherapy Sarcopenia Ulcers Young adults |
| title | Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study |
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