Activity of multipurpose contact lens solutions against Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens and Candida albicans biofilms

Introduction The use of contact lenses has progressively increased around the world, thereby increasing the risk of complications. The most serious complication is microbial keratitis (corneal infection) that can progress to a corneal ulcer. Methods Fourteen multipurpose contact lens solutions were...

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Bibliographic Details
Published in:Ophthalmic & physiological optics 2023-09, Vol.43 (5), p.1092-1099
Main Authors: Mendonca, Jamile Reimann, Dantas, Leticia Ramos, Tuon, Felipe Francisco
Format: Article
Language:English
Subjects:
bacterial keratitis
Biofilms
Candida albicans
contact lens
Contact lenses
Cornea
corneal ulcer
Disinfection
Eradication
Fungicidal activity
Keratitis
multipurpose contact lens solution
Planktonic cells
Pseudomonas aeruginosa
Serratia marcescens
Staphylococcus aureus
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Summary:Introduction The use of contact lenses has progressively increased around the world, thereby increasing the risk of complications. The most serious complication is microbial keratitis (corneal infection) that can progress to a corneal ulcer. Methods Fourteen multipurpose contact lens solutions were tested on mature biofilms comprising Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens and Candida albicans, using the minimum disinfection times recommended by the manufacturers. The biofilm was induced in the lens case, and 24 h later, the solutions were added. Activity against planktonic and sessile cells was evaluated and quantified as colony forming units per millilitre. The minimum concentration for biofilm eradication was defined as a 99.9% reduction in viable cells. Results Although most solutions exhibited activity against planktonic cells, only five of the 14 solutions produced a significant reduction in the S. marcescens biofilm. No solution achieved the minimal biofilm eradication of S. aureus, P. aeruginosa and C. albicans. Conclusion Multipurpose contact lens solutions provide greater bactericidal and/or fungicidal activity on planktonic cells than biofilms. The minimal eradication biofilm concentration was only achieved for S. marcescens.
ISSN:0275-5408
1475-1313
DOI:10.1111/opo.13189