Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)

Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cas...

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Published in:International journal of cancer 2023-09, Vol.153 (5), p.979-993
Main Authors: Palomar-Cros, Anna, Straif, Kurt, Romaguera, Dora, Aragonés, Nuria, Castaño-Vinyals, Gemma, Martin, Vicente, Moreno, Victor, Gómez-Acebo, Inés, Guevara, Marcela, Aizpurua, Amaia, Molina-Barceló, Ana, Jiménez-Moleón, José-Juan, Tardón, Adonina, Contreras-Llanes, Manuel, Marcos-Gragera, Rafael, Huerta, José Mª, Pérez-Gómez, Beatriz, Espinosa, Ana, Hernández-Segura, Natalia, Obón-Santacana, Mireia, Alonso-Molero, Jessica, Burgui, Rosana, Amiano, Pilar, Pinto-Carbó, Marina, Olmedo-Requena, Rocio, Fernández-Tardón, Guillermo, Santos-Sánchez, Vanessa, Fernández de Larrea-Baz, Nerea, Fernández-Villa, Tania, Casabonne, Delphine, Dierssen-Sotos, Trinidad, Ardanaz, Eva, Dorronsoro, Ane, Pollán, Marina, Kogevinas, Manolis, Lassale, Camille
Format: Article
Language:English
Subjects:
Artificial sweeteners
Aspartame - adverse effects
Beverages
Breast cancer
Cancer
Chronic lymphocytic leukemia
Colorectal carcinoma
Consumers
Diabetes
Diabetes Mellitus
Female
Gastric cancer
Humans
Male
Medical research
Prostate cancer
Regression analysis
Saccharin
Spain - epidemiology
Stomach
Stomach Neoplasms - chemically induced
Stomach Neoplasms - epidemiology
Sucralose
Sweeteners
Sweetening Agents - adverse effects
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Summary:Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.34577