Interactions of the bacteriome, virome, and immune system in the nose

Emerging evidence suggests that the nasal microbiome may influence host susceptibility to initial development and severity of respiratory viral infections. While not as extensively studied as the microbiota of the alimentary tract, it is now clearly established that the microbial composition of this...

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Bibliographic Details
Published in:FEMS microbes 2022, Vol.3, p.xtac020-xtac020
Main Authors: Flynn, Matthew, Lyall, Zinnia, Shepherd, Gwendolyn, Lee, Osher Ngo Yung, Marianna Da Fonseca, Ioannou, Dong, Yijia, Chalmers, Stuart, Hare, Jamie, Thomson, Jack, Millar, Freya
Format: Article
Language:English
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Summary:Emerging evidence suggests that the nasal microbiome may influence host susceptibility to initial development and severity of respiratory viral infections. While not as extensively studied as the microbiota of the alimentary tract, it is now clearly established that the microbial composition of this niche is influenced by medical, social and pharmacological influences, predisposing some sub-populations to respiratory infections. The resulting specific microbial profiles may explain variance in susceptibility to viral infection. This review summaries the evolution and constituents of the commensal nasal microbiome; the bacterial-virus, bacterial-host and interbacterial interactions which potentiate disease; and considers the effects of interventions such as vaccination and probiotics.
ISSN:2633-6685
2633-6685
DOI:10.1093/femsmc/xtac020