Cytokine Profile and Concentrations of Metabolic Hormones in the Blood of Overweight Men with Coronary Arteriosclerosis

• Published in: Bulletin of experimental biology and medicine 2023-05, Vol.175 (1), p.92-95
• Main Authors: Stryukova, E. V., Shramko, V. S., Kashtanova, E. V., Polonskaya, Ya. V., Stakhneva, E. M., Kurguzov, A. V., Chernyavskiy, A. M., Ragino, Yu. I.
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Analysis; Arteriosclerosis; Atherosclerosis; Biomedical and Life Sciences; Biomedicine; Blood Glucose - metabolism; Body weight; Cell Biology; Coronary artery; Coronary Artery Disease; Cytokines; Experimental Methods for Clinical Practice; Female; Gastric Inhibitory Polypeptide - metabolism; GIP protein; Glucagon; Glucagon-like peptide 1; Hormones; Humans; Insulin; Interleukin 6; Internal Medicine; Laboratory Medicine; Leptin; Male; Metabolism; Middle Aged; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Overweight; Overweight - complications; Overweight persons; Pathology; Peptides; Plaque, Atherosclerotic; Plaques; Plasma levels; Type 2 diabetes
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-023-05817-y

Plasma concentrations of cytokines and metabolic hormones and their association with vulnerable atherosclerotic plaques were studied in 36 overweight men (age 40-77 years; BMI 25.0-29.9 kg/m 2 ) with coronary atherosclerosis who underwent coronary endarterectomy. According to histological analysis, the patients were divided into two groups: with stable (17 (47.2%) men) and vulnerable (19 (52.8%) men) plaques in the coronary arteries. The plasma levels of cytokines and metabolic hormones were measured by multiplex analysis: C-peptide, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1, glucagon, IL-6, insulin, leptin, monocyte chemoattractant protein-1, and TNFα. In overweight patients with vulnerable plaques, the level of glucagon was lower by 4.17 times, GIP — by 2.47 times, and insulin — by 2.1 times. At the same time, the risk of occurrence of a vulnerable plaque increases by 5.4% with a decrease in GIP concentration by 1 pg/ml irrespectively of age, as well as by 3.1% with an increase in insulin concentration by 10 pg/ml, without achieving statistical significance when included in the age model. Overweight men with coronary atherosclerosis and vulnerable plaques have lower levels of insulin, glucagon, and GIP. The levels of GIP and insulin are inversely associated with the risk of having vulnerable atherosclerotic plaque.