Vitamin D and diabetic peripheral neuropathy: A multi-centre nerve conduction study among Chinese patients with type 2 diabetes

Increasing numbers of reports link vitamin D deficiency to diabetic peripheral neuropathy (DPN), yet evidence regarding neurological deficits and electromyogram is scarce. The present multi-centre study sought to investigate these associations based on objective quantifications. Information on DPN-r...

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Published in:Diabetes/metabolism research and reviews 2023-10, Vol.39 (7), p.e3679-e3679
Main Authors: Pang, Chunyang, Yu, Huan, Cai, Yunlei, Song, Mengwan, Feng, Fei, Gao, Lingfei, Li, Kezheng, Chen, Yinuo, Xie, Jiali, Cheng, Yifan, Lin, Er, Pan, Xinnan, Zhang, Wanli, Deng, Binbin
Format: Article
Language:English
Subjects:
Ankle
Diabetes
Diabetes mellitus (non-insulin dependent)
Electromyography
Latency
Microvasculature
Nephropathy
Nerve conduction
Nervous system
Neurological diseases
Peripheral nerves
Peripheral neuropathy
Retinopathy
Sensory neurons
Velocity
Vitamin D
Vitamin deficiency
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Summary:Increasing numbers of reports link vitamin D deficiency to diabetic peripheral neuropathy (DPN), yet evidence regarding neurological deficits and electromyogram is scarce. The present multi-centre study sought to investigate these associations based on objective quantifications. Information on DPN-related symptoms, signs, all diabetic microvascular complications, and nerve conduction abilities (quantified by nerve conduction amplitude and velocity, F-wave minimum latency (FML) of peripheral nerves) were collected from a derivation cohort of 1192 patients with type 2 diabetes (T2D). Correlation, regression analysis, and restricted cubic splines (RCS) were used to explore linear and non-linear relationships between vitamin D and DPN, which were validated in an external cohort of 223 patients. Patients with DPN showed lower levels of vitamin D than those without DPN; patients with vitamin D deficiency (
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3679