Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol

The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight. The concentration of succinate in blood plasma, cytoplasmic and mitochondrial fractions of cells of the cerebral cortex, left-ventricular myocardium, and...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-05, Vol.175 (1), p.54-58
Main Authors: Shchulkin, A. V., Mylnikov, P. Yu, Chernykh, I. V., Esenina, A. S., Yakusheva, E. N.
Format: Article
Language:English
Subjects:
Administration, Intravenous
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Blood levels
Body weight
Cell Biology
Cerebral cortex
Heart
Internal Medicine
Intravenous administration
Laboratory Medicine
Liver
Myocardium
Pathology
Pharmacokinetics
Rats
Rats, Wistar
Succinic Acid
Tandem Mass Spectrometry
Ventricle
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Summary:The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight. The concentration of succinate in blood plasma, cytoplasmic and mitochondrial fractions of cells of the cerebral cortex, left-ventricular myocardium, and liver was measured by HPLC-MS/MS. After single intravenous administration of Mexidol, succinate was evenly distributed in organs and tissues and quickly eliminated from the body. The pharmacokinetics of succinate was described by a two-chamber model. An increase in the level of succinate in the cytoplasmic fraction of the liver, myocardium, and cerebral cortex cells and a minor increase in the mitochondrial fraction were observed. The maximum increase in the level of succinate in the cytoplasmic fraction was observed in the liver tissue, a less pronounced elevation was observed in the cerebral cortex and myocardium; no significant differences between the cerebral cortex and myocardium were observed by this parameter.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05810-5