The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline

Spontaneous bioelectrical activity of the brain and the duration of gasping were recorded in mice during modeling of global strangulation ischemia of the brain against the background of preventive administration of citicoline. The maximum neuroprotective effect of citicoline was observed when it was...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-05, Vol.175 (1), p.45-48
Main Authors: Sufianova, G. Z., Shapkin, A. G., Khlestkina, M. S., Maslov, L. N., Mukhomedzyanov, A. V., Voronkov, N. S., Sufianov, A. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cardiology
Cell Biology
Citicoline
Internal Medicine
Ischemia
Laboratory Medicine
Neuroprotection
Neurosurgery
Pathology
Pharmacology
Receptor mechanisms
Respiration
Strangulation
Toxicology
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Summary:Spontaneous bioelectrical activity of the brain and the duration of gasping were recorded in mice during modeling of global strangulation ischemia of the brain against the background of preventive administration of citicoline. The maximum neuroprotective effect of citicoline was observed when it was administered 60 min before the simulation of ischemia and was completely prevented by preliminary administration of a selective P 2 Y 6 receptor antagonist MRS2578. The obtained experimental data attest to the leading role of receptor mechanisms in the implementation of neuroprotective activity of citicoline.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05808-z