k-Carrageenan based magnetic@polyelectrolyte complex composite hydrogel for pH and temperature-responsive curcumin delivery

The dual stimuli-responsive drug delivery system has attracted a lot of interest in controlled drug delivery to specific sites. The magnetic iron oxide nanoparticles integrated polyelectrolyte complex-based hydrogel (MPEC HG) system was developed in this work. First, magnetic nanoparticles were prod...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-07, Vol.244, p.125467-125467, Article 125467
Main Authors: Santhamoorthy, Madhappan, Thirupathi, Kokila, Kumar, Sathish Sundar Dhilip, Pandiaraj, Saravanan, Rahaman, Mostafizur, Phan, Thi Tuong Vy, Kim, Seong-Cheol
Format: Article
Language:English
Subjects:
Carrageenan
Curcumin - chemistry
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems - methods
Drug Liberation
HepG2 cells
Humans
Hydrogels - chemistry
Hydrogen-Ion Concentration
Magnetic nanoparticles
Magnetic Phenomena
pH and temperature-stimuli
Polyelectrolyte complex
Polyelectrolytes - chemistry
Temperature
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Summary:The dual stimuli-responsive drug delivery system has attracted a lot of interest in controlled drug delivery to specific sites. The magnetic iron oxide nanoparticles integrated polyelectrolyte complex-based hydrogel (MPEC HG) system was developed in this work. First, magnetic nanoparticles were produced in situ in the synthetic polymer polyhexamethylene guanidine (PHMG). Furthermore, the natural biopolymer k-carrageenan (kCG) was employed to form the polyelectrolyte complex (PEC) through charge-balancing interaction between positively charged guanidine units and negatively charged sulfonate groups. Various characterization approaches were used to characterize the developed magnetic polyelectrolyte complex hydrogel (MPEC HG) system. Curcumin (Cur) was employed as a model bioactive agent to examine the drug loading and stimuli-responsive drug release efficiency of the MPEC HG system. Under the combined pH and temperature stimuli conditions (pH 5.0/42 °C), the developed hydrogel system demonstrated great drug loading efficiency (∼ 68 %) and enhanced drug release. Furthermore, the MPEC HG system's in vitro cytotoxicity behavior was investigated on a human liver cancer (HepG2) cell line, and the results revealed that the MPEC HG system is biocompatible. As a result, the MPEC HG system might be used for dual pH and temperature stimuli-responsive drug delivery applications in cancer therapy.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.125467