Gingival metastasis of angiosarcoma of the breast as a first manifestation of spreading disease: Case report and review of the literature

Background Angiosarcoma is an aggressive malignant neoplasm of vascular origin. Oral metastases of angiosarcoma are rare and have a non‐specific clinical presentation, thus the diagnosis may be challenging. Case report Herein we report a case of a 34‐year‐old female patient after treatment of a high...

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Bibliographic Details
Published in:Special care in dentistry 2024-03, Vol.44 (2), p.458-464
Main Authors: Mota, Maria Emília, Tomo, Saygo, Alves, Fábio de Abreu, Pellissari, Guilherme Andrade, do Nascimento, Antonio Geraldo, Lopes, Rodrigo Nascimento
Format: Article
Language:English
Subjects:
Adult
angiosarcoma
Biopsy
Bone lesions
Breast
Breast Neoplasms
Case reports
Chemotherapy
Differential diagnosis
Female
Gingiva - pathology
Hemangiosarcoma - diagnosis
Hemangiosarcoma - pathology
Hemangiosarcoma - therapy
Humans
Literature reviews
Malignancy
Metastases
Metastasis
Neoplasia
oral
Oral cancer
Patients
Radiation therapy
Tumors
Citations: Items that this one cites
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Summary:Background Angiosarcoma is an aggressive malignant neoplasm of vascular origin. Oral metastases of angiosarcoma are rare and have a non‐specific clinical presentation, thus the diagnosis may be challenging. Case report Herein we report a case of a 34‐year‐old female patient after treatment of a high‐grade angiosarcoma of the breast, who presented an asymptomatic bleeding purplish nodule in the maxillary interdental papilla between the first and second premolar. A biopsy was performed, and the histological examination revealed infiltration by malignant neoplasm of epithelioid and fusocellular pattern. Immunohistochemical analysis demonstrated that neoplastic cells were positive for ERG and CD31, and negative for cytokeratins AE1/AE3, confirming the diagnosis of metastatic angiosarcoma. After investigation, multiple metastases were discovered. The patient is under management with chemotherapy and palliative radiotherapy for the bone lesions. Conclusion Metastases should be considered in the differential diagnosis of oral lesions in patients with a previous history of cancer. Due to the morphology of angiosarcomas, the metastatic lesions may resemble benign vascular lesions, therefore, biopsy is mandatory to exclude malignancy.
ISSN:0275-1879
1754-4505
DOI:10.1111/scd.12896