Prognostic Assessment of Fractional Flow Reserve in Different Strata in Patients with Coronary Artery Disease

• Published in: Arquivos brasileiros de cardiologia 2023-05, Vol.120 (6), p.e20211051-e20211051
• Main Authors: Pellegrini, Denise, Caramori, Paulo R A, Soccol, Ricardo Czarnobai, Lasevitch, Ricardo, Agostini, Gustavo Luís, Dussin, Alice, Ferreira, Flavio Vinicius Costa, Wagner, Mario Bernardes, Bodanese, Luiz Carlos
• Format: Article
• Language: English
• Subjects: Coronary Artery Disease - diagnosis; Female; Fractional Flow Reserve, Myocardial; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis
• ISSN: 1678-4170
• DOI: 10.36660/abc.20211051

There are limited real-world data on the clinical course of untreated coronary lesions according to their functional severity. To evaluate the 5-year clinical outcomes of patients with revascularized lesions with fractional flow reserve (FFR) ≤ 0.8 and patients with non-revascularized lesions with FFR > 0.8. The FFR assessment was performed in 218 patients followed for up to 5 years. Participants were classified based on FFR into ischemia group (≤ 0.8, intervention group, n = 55), low-normal FFR group (> 0.8-0.9, n = 91), and high-normal FFR group (> 0.9, n = 72). The primary endpoint was major adverse cardiac events (MACEs), a composite of death, myocardial infarction, and need for repeat revascularization. The significance level was set at 0.05; therefore, results with a p-value < 0.05 were considered statistically significant. Most patients were male (62.8%) with a mean age of 64.1 years. Diabetes was present in 27%. On coronary angiography, the severity of stenosis was 62% in the ischemia group, 56.4% in the low-normal FFR group, and 54.3% in the high-normal FFR group (p