Effects of induced electric fields on finite neuronal structures: a simulation study

An analysis is presented of magnetic stimulation of finite length neuronal structures using computer simulations. Models of finite neuronal structures in the presence of extrinsically applied electric fields indicate that excitation can be characterized by two driving functions: one due to field gra...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1993-11, Vol.40 (11), p.1175-1188
Main Authors: Nagarajan, S.S., Durand, D.M., Warman, E.N.
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Biological and medical sciences
Computational modeling
Computer Simulation
Dendrites - physiology
Electromagnetic Fields
Investigative techniques, diagnostic techniques (general aspects)
Magnetic analysis
Magnetic stimulation
Mammals
Medical sciences
Models, Neurological
Nerve fibers
Nervous system
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Physical Stimulation - methods
Shape
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An analysis is presented of magnetic stimulation of finite length neuronal structures using computer simulations. Models of finite neuronal structures in the presence of extrinsically applied electric fields indicate that excitation can be characterized by two driving functions: one due to field gradients and the other due to fields at the boundaries of neuronal structures. It is found that boundary field driving functions play an important role in governing excitation characteristics during magnetic stimulation. Simulations indicate that axons whose lengths are short compared to the spatial extent of the induced field are easier to excite than longer axons of the same diameter. Simulations also indicate that independent cellular dendritic processes are probably not excited during magnetic stimulation. Analysis of the temporal distribution of induced fields indicates that the temporal shape of the stimulus waveform modulates excitation thresholds and propagation of action potentials.< >
ISSN:0018-9294
1558-2531
DOI:10.1109/10.245636