Nonenzymatic Electrochemical Sensing Platform Based on 2D Isomorphic Co/Ni-Metal–Organic Frameworks for Glucose Detection

• Published in: Inorganic chemistry 2023-07, Vol.62 (26), p.10256-10262
• Main Authors: Wang, Xin-Ying, Yan, Xue-Xue, Wu, Ya-Pan, Wu, Xue-Qian, Yin, Ya-Meng, Li, Shuang, Zhang, Qichun, Liu, Bin, Li, Dong-Sheng
• Format: Article
• Language: English
• Subjects: Acetylene; Carbon - chemistry; Electrodes; Glucose - chemistry; Metal-Organic Frameworks - chemistry; Nickel - chemistry
• ISSN: 0020-1669; 1520-510X
• DOI: 10.1021/acs.inorgchem.3c01058

Two-dimensional metal–organic framework (MOF) crystalline materials possess promising potential in the electrochemical sensing process owing to their tunable structures, high specific surface area, and abundant metal active sites; however, developing MOF-based nonenzymatic glucose (Glu) sensors which combine electrochemical activity and environmental stability remains a challenge. Herein, utilizing the tripodic nitrogen-bridged 1,3,5-tris­(1-imidazolyl) benzene (TIB) linker, Co2+ and Ni2+, two 2D isomorphic crystalline materials, including Co/Ni-MOF {[Co (TIB)]·2BF4} (CTGU-31) and {[Ni­(TIB)]·2NO3} (CTGU-32), with a binodal (3, 6)-connected kgd topological net were firstly synthesized and fabricated with conducting acetylene black (AB). When modified on a glassy carbon electrode, the optimized AB/CTGU-32 (1:1) electrocatalyst demonstrated a higher sensitivity of 2.198 μA μM–1 cm–2, a wider linear range from 10 to 4000 μM, and a lower detection limit (LOD) value (0.09 μM, S/N = 3) compared to previously MOF-based Glu sensors. Moreover, AB/CTGU-32 (1:1) exhibited desirable stability for at least 2000 s during the electrochemical process. The work indicates that MOF-based electrocatalysts are a promising candidate for monitoring Glu and demonstrate their potential for preliminary screening for diabetes.