Elsholblanosides A−D, Four New Oleuropeic Acid Derivatives Isolated from Elsholtzia blanda and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells

Phytochemical investigation on the aerial parts of Elsholtzia blanda Benth. afforded four new oleuropeic acid derivatives (1–4), named as elsholblanosides A−D, respectively, together with 11 known compounds (5–15). Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D...

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Published in:Chemistry & biodiversity 2023-08, Vol.20 (8), p.e202300785-n/a
Main Authors: Thi Dung, Duong, Thi Trang, Do, Hai yen, Pham, Huy Hoang, Nguyen, Huu Tai, Bui, Van Kiem, Phan
Format: Article
Language:English
Subjects:
Dexamethasone
elsholblanoside A
elsholblanoside B
elsholblanoside C
elsholblanoside D
Elsholtzia
Elsholtzia blanda
NMR
Nuclear magnetic resonance
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creator Thi Dung, Duong
Thi Trang, Do
Hai yen, Pham
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Huu Tai, Bui
Van Kiem, Phan
description Phytochemical investigation on the aerial parts of Elsholtzia blanda Benth. afforded four new oleuropeic acid derivatives (1–4), named as elsholblanosides A−D, respectively, together with 11 known compounds (5–15). Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR, and ECD spectra. Compounds 1–4 and 14 showed moderate NO production inhibition in LPS‐activated RAW264.7 cells with their IC50 values ranging from 23.2 to 86.33 μM, compared to that of the positive control compound, dexamethasone, IC50 value of 16.9 μM.
doi_str_mv 10.1002/cbdv.202300785
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subjects Dexamethasone
elsholblanoside A
elsholblanoside B
elsholblanoside C
elsholblanoside D
Elsholtzia
Elsholtzia blanda
NMR
Nuclear magnetic resonance
title Elsholblanosides A−D, Four New Oleuropeic Acid Derivatives Isolated from Elsholtzia blanda and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells
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