Comparison of HBV DNA and RNA markers in Alaska Native people who did and did not clear hepatitis B surface antigen

In a comparison between 50 Alaska Native persons with chronic hepatitis B who cleared HBV surface antigen (HBsAg) and 50 Alaska Native age‐, sex‐, and HBV genotype‐matched controls, we found differences in changes in HBV DNA and HBV RNA levels over time but no difference in hepatitis B core‐related...

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Bibliographic Details
Published in:Journal of viral hepatitis 2023-09, Vol.30 (9), p.727-730
Main Authors: Johnston, Janet M., McMahon, Brian, Simons, Brenna C., Homan, Chriss
Format: Article
Language:English
Subjects:
biomarkers
chronic hepatitis B
Deoxyribonucleic acid
DNA
Genotypes
Hepatitis B
hepatitis B Core antigens
Hepatitis B surface antigen
hepatitis B surface antigens
Ribonucleic acid
RNA
seroconversion
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Summary:In a comparison between 50 Alaska Native persons with chronic hepatitis B who cleared HBV surface antigen (HBsAg) and 50 Alaska Native age‐, sex‐, and HBV genotype‐matched controls, we found differences in changes in HBV DNA and HBV RNA levels over time but no difference in hepatitis B core‐related antigen. These findings suggest that serial HBV DNA and HBV RNA may be associated with HBV functional cure defined by HBsAg clearance.
ISSN:1352-0504
1365-2893
DOI:10.1111/jvh.13867