Epithelial Tight Junction Anomalies in Nasal Inverted Papilloma

Objectives As a critical component of the epithelial barrier, tight junctions (TJs) are essential in nasal mucosa against pathogen invasion. However, the function of TJs has rarely been reported in nasal inverted papilloma (NIP). This study aims to investigate the potential factors of TJs' abno...

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Published in:The Laryngoscope 2024-02, Vol.134 (2), p.552-561
Main Authors: Huang, Zhi‐Qun, Zhou, Xiang‐Min, Yuan, Tian, Liu, Jing, Ong, Hsiao H., Sun, Li‐Ying, Tu, Jun‐Hao, Li, Meng‐Yue, Thong, Kim T. M., Ye, Jing, Shi, Li, Wang, De‐Yun, Xu, Yu
Format: Article
Language:English
Subjects:
Mucous membrane
nasal inverted papilloma
neutrophils
Nose
Otolaryngology
regulatory T cells
TH1/TH2/TH17
tight junctions
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Summary:Objectives As a critical component of the epithelial barrier, tight junctions (TJs) are essential in nasal mucosa against pathogen invasion. However, the function of TJs has rarely been reported in nasal inverted papilloma (NIP). This study aims to investigate the potential factors of TJs' abnormality in NIP. Methods We assessed the expression of ZO‐1, occludin, claudin‐1, claudin‐3, and claudin‐7 in healthy controls and NIP by real‐time quantitative polymerase chain reaction and immunofluorescent staining. The correlation between TJs expression and neutrophil count, TH1/TH2/TH17 and regulatory T cell biomarkers, and the proportion of nasal epithelial cells was investigated. Results Upregulation of ZO‐1, occludin, claudin‐1, and claudin‐7, along with downregulation of claudin‐3, was found in NIP compared to control (all p 
ISSN:0023-852X
1531-4995
1531-4995
DOI:10.1002/lary.30845