Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer

The human intestine is a habitat for microorganisms and, recently, the composition of the intestinal microbiota has been correlated with the etiology of diseases such as inflammations, sores, and tumors. Although many studies have been conducted to understand the composition of that microbiota, expa...

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Bibliographic Details
Published in:Folia microbiologica 2024-04, Vol.69 (2), p.333-345
Main Authors: Acar, Ceren, Celik, Sibel Kucukyildirim, Ozdemirel, H. Ozgur, Tuncdemir, Beril Erdem, Alan, Saadet, Mergen, Hatice
Format: Article
Language:English
Subjects:
Applied Microbiology
Bacteria
Biomedical and Life Sciences
Biopsy
Colon
Colon cancer
Colorectal cancer
Composition
Environmental Engineering/Biotechnology
Immunology
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Life Sciences
Metagenomics
Microbiology
Microbiota
Microorganisms
Original Article
Relative abundance
Tumors
Ulcerative colitis
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Summary:The human intestine is a habitat for microorganisms and, recently, the composition of the intestinal microbiota has been correlated with the etiology of diseases such as inflammations, sores, and tumors. Although many studies have been conducted to understand the composition of that microbiota, expanding these studies to more samples and different backgrounds will improve our knowledge. In this work, we showed the colon microbiota composition and diversity of healthy subjects, patients with inflammatory bowel disease (IBD), and colon cancer by metagenomic sequencing. Our results indicated that the relative abundance of prokaryotic and eukaryotic microbes differs between the healthy vs. tumor biopsies, tumor vs. IBD biopsies, and fresh vs. paraffin-embedded tumor biopsies. Fusobacterium , Escherichia-Shigella , and Streptococcus genera were relatively abundant in fresh tumor biopsies, while Pseudomonas was significantly elevated in IBD biopsies. Additionally, another opportunist pathogen Malasseziales was revealed as the most abundant fungal clade in IBD biopsies, especially in ulcerative colitis. We also found that, while the Basidiomycota:Ascomycota ratio was slightly lower in tumor biopsies compared to biopsies from healthy subjects, there was a significant increase in IBD biopsies. Our work will contribute to the known diversity of prokaryotic and eukaryotic microbes in the colon biopsies in patients with IBD and colon cancer.
ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-023-01072-w