Comparative study of fibroblast growth factor 2 and ofloxacin ear drops for repairing large traumatic perforations: A randomized controlled study

• Published in: American journal of otolaryngology 2023-09, Vol.44 (5), p.103954-103954, Article 103954
• Main Authors: Ding, Yongqing, Wei, Ruili, Li, Dong, Li, Yanping, Tian, Zedong, Xie, Qi, Liu, Yachao
• Format: Article
• Language: English
• Subjects: Healing; Ofloxacin ear drops; Perforation; Traumatic; Tympanic membrane
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2023.103954

The objective of this study was to compare the healing outcome of fibroblast growth factor 2 (FGF2), ofloxacin ear drops (OFLX) and spontaneous healing for repairing large traumatic tympanic membrane (TM) perforations. A total of 75 traumatic large perforations with >1/4 of TM were randomly divided into FGF2 (n = 25), OFLX (n = 25), and spontaneous healing (n = 25) groups. The closure rates, closure times, and hearing gains were compared at 3 months. At 2 weeks after treatment, the closure rate was 95.8 % in the FGF2 group, 96.0 % in the ofloxacin ear drops group, and 14.3 % in the spontaneous healing group (P  0.05). The mean closure time was 9.69 ± 2.46 days in the FGF2 group, 9.45 ± 2.32 days in the OFLX group, and 30.94 ± 8.95 days in the spontaneous healing group (P  0.05). This study suggested that both FGF2 and OFLX significantly shortened the mean closure time and improved the closure rate compared with spontaneous healing for repairing large traumatic perforations, while the healing outcome wasn't significantly different among FGF2 and OFLX groups.