Utility of non-invasive liver fibrosis markers to predict the incidence of chronic kidney disease (CKD): A systematic review, meta-analysis, and meta-regression

Chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) share common risk factors and pathogenesis mechanisms. However, the association between the degree of liver fibrosis and the incidence of CKD remains unclear. This study aims to examine the utility of non-invasive fibrosis ma...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2023-08, Vol.17 (8), p.102814-102814, Article 102814
Main Authors: Supriyadi, Rudi, Yanto, Theo Audi, Hariyanto, Timotius Ivan, Suastika, Ketut
Format: Article
Language:English
Subjects:
Aminotransferase
Diagnostic
Fibrosis index
Liver fibrosis
Renal insufficiency
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Summary:Chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) share common risk factors and pathogenesis mechanisms. However, the association between the degree of liver fibrosis and the incidence of CKD remains unclear. This study aims to examine the utility of non-invasive fibrosis markers to predict the occurrence of CKD. Cochrane Library, Scopus, and Medline were searched up to May 20th, 2023 using combined keywords. Literature that analyzes FIB-4, NFS, and APRI to predict CKD incidence was included in this review. We used random-effect models of odds ratio (OR) with 95% confidence intervals (CI) to express the outcomes in this review. Twenty-one studies were included. Our meta-analysis showed that high FIB-4 was associated with a higher incidence of CKD (OR 2.51; 95%CI: 1.87–3.37, p 
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2023.102814