Obesity and diabetes

Obesity, which has currently reached pandemic dimensions, is usually accompanied by diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological mechanisms. Adipose tissue secretes cytokines which are involved in inflammation and various endocrine functions. As for T2DM, it...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2023-08, Vol.202, p.110773-110773, Article 110773
Main Authors: Boutari, Chrysoula, DeMarsilis, Antea, Mantzoros, Christos S.
Format: Article
Language:English
Subjects:
Antidiabetics
Cardiovascular disease
Cytokines
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - therapy
Humans
Inflammation - complications
Non-alcoholic Fatty Liver Disease - complications
Nonalcoholic fatty liver disease
Obesity
Obesity - complications
Obesity - epidemiology
Obesity - therapy
T2DM management
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Summary:Obesity, which has currently reached pandemic dimensions, is usually accompanied by diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological mechanisms. Adipose tissue secretes cytokines which are involved in inflammation and various endocrine functions. As for T2DM, it is characterized also by inflammation, mitochondrial dysfunction, and hyperinsulinemia. These conditions occur also in other diseases related to obesity and T2DM, like cardiovascular disease (CVD) and nonalcoholic fatty liver disease (NAFLD). Thus, management of obesity-related complications with lifestyle modification, anti-obesity drugs, and bariatric surgery, all contribute to improvement in any of these conditions. This review provides an overview of the literature addressing the association between obesity and T2DM, briefly discussing the pathophysiological mechanisms linking these conditions and outlining the management approach at the overlap of obesity and T2DM.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2023.110773