Treatment Guidelines for Hyponatremia: Stay the Course

International guidelines designed to minimize the risk of complications that can occur when correcting severe hyponatremia have been widely accepted for a decade. On the basis of the results of a recent large retrospective study of patients hospitalized with hyponatremia, it has been suggested that...

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Published in:Clinical journal of the American Society of Nephrology 2024-01, Vol.19 (1), p.129-135
Main Authors: Sterns, Richard H, Rondon-Berrios, Helbert, Adrogué, Horacio J, Berl, Tomas, Burst, Volker, Cohen, David M, Christ-Crain, Mirjam, Cuesta, Martin, Decaux, Guy, Emmett, Michael, Garrahy, Aoife, Gankam-Kengne, Fabrice, Hix, John K, Hoorn, Ewout J, Kamel, Kamel S, Madias, Nicolaos E, Peri, Alessandro, Refardt, Julie, Rosner, Mitchell H, Sherlock, Mark, Silver, Stephen M, Soupart, Alain, Thompson, Chris J, Verbalis, Joseph G
Format: Article
Language:English
Subjects:
Humans
Hyponatremia - blood
Hyponatremia - diagnosis
Hyponatremia - therapy
Practice Guidelines as Topic
Severity of Illness Index
Sodium - blood
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Summary:International guidelines designed to minimize the risk of complications that can occur when correcting severe hyponatremia have been widely accepted for a decade. On the basis of the results of a recent large retrospective study of patients hospitalized with hyponatremia, it has been suggested that hyponatremia guidelines have gone too far in limiting the rate of rise of the serum sodium concentration; the need for therapeutic caution and frequent monitoring of the serum sodium concentration has been questioned. These assertions are reminiscent of a controversy that began many years ago. After reviewing the history of that controversy, the evidence supporting the guidelines, and the validity of data challenging them, we conclude that current safeguards should not be abandoned. To do so would be akin to discarding your umbrella because you remained dry in a rainstorm. The authors of this review, who represent 20 medical centers in nine countries, have all contributed significantly to the literature on the subject. We urge clinicians to continue to treat severe hyponatremia cautiously and to wait for better evidence before adopting less stringent therapeutic limits.
ISSN:1555-9041
1555-905X
1555-905X
DOI:10.2215/CJN.0000000000000244