Identification of Potential Bioactive Compounds from Aspergillus terreus against HCV NS3 Serine Protease

This study was aimed to isolate bioactive compounds from the fermentation products of Aspergillus terreus, which could inhibit NS3 protease of hepatitis C virus (HCV). The bioactive compounds were isolated by reverse‐phase silica‐gel column chromatography, semi‐preparative reversed‐phase, and Sephad...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-08, Vol.20 (8), p.e202300532-n/a
Main Authors: Lin, Jun, Yang, Li‐Yuan, Pan, Zhi‐Di
Format: Article
Language:English
Subjects:
antiviral
Aspergillus terreus
Benzaldehyde
bioactive compound
Bioactive compounds
Biological activity
Column chromatography
Drug development
Fermentation
HCV NS3 protease
Hepatitis C
Microorganisms
Protease
Proteinase
Silica
Silica gel
Viruses
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Summary:This study was aimed to isolate bioactive compounds from the fermentation products of Aspergillus terreus, which could inhibit NS3 protease of hepatitis C virus (HCV). The bioactive compounds were isolated by reverse‐phase silica‐gel column chromatography, semi‐preparative reversed‐phase, and Sephadex LH‐20, and then their structures were elucidated through spectroscopic analysis. As a result, two small molecule compounds were isolated. Compound 1 was identified as a new benzaldehyde, (E)‐2,4‐dihydroxy‐6‐propenylbenzaldehyde. Compound 2 was identified as pleurone, which was obtained from microorganisms for the first time. Their inhibitory activities against HCV NS3 protease (IC50) were 32.6 μM and 78.9 μM, respectively. This study provided a new option for the development of anti‐HCV drugs.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300532