The Pathological Mechanism of Neuronal Autophagy-Lysosome Dysfunction After Ischemic Stroke

The abnormal initiation of autophagy flux in neurons after ischemic stroke caused dysfunction of autophagy-lysosome, which not only led to autophagy flux blockage, but also resulted in autophagic death of neurons. However, the pathological mechanism of neuronal autophagy-lysosome dysfunction did not...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2023-10, Vol.43 (7), p.3251-3263
Main Authors: Shi, Guang-Sen, Qin, Qi-Lin, Huang, Cheng, Li, Zi-Rong, Wang, Zi-Han, Wang, Yong-Yan, He, Xiu-Ying, Zhao, Xiao-Ming
Format: Article
Language:English
Subjects:
Autophagy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Ischemia
Molecular modelling
Neurobiology
Neurons
Neurosciences
Review Paper
Stroke
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Summary:The abnormal initiation of autophagy flux in neurons after ischemic stroke caused dysfunction of autophagy-lysosome, which not only led to autophagy flux blockage, but also resulted in autophagic death of neurons. However, the pathological mechanism of neuronal autophagy-lysosome dysfunction did not form a unified viewpoint until now. In this review, taking the autophagy lysosomal dysfunction of neurons as a starting point, we summarized the molecular mechanisms that led to neuronal autophagy lysosomal dysfunction after ischemic stroke, which would provide theoretical basis for the clinical treatment of ischemic stroke. Graphical Abstract
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-023-01382-0