Recent Advances in Aerobic Oxidative of C-H Bond by Molecular Oxygen Focus on Heterocycles

Aerobic oxidative cross-coupling represents one of the most straightforward and atom-economic methods for construction of C-C and C-X (X=N, O, S, or P) bonds using air as a sustainable external oxidant. The oxidative coupling of C-H bonds in heterocyclic compounds can effectively increase their mole...

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Bibliographic Details
Published in:Chemistry : a European journal 2023-09, Vol.29 (51), p.e202301700-e202301700
Main Authors: Zhang, Lei-Yang, Wang, Nai-Xing, Lucan, Dumitra, Cheung, William, Xing, Yalan
Format: Article
Language:English
Subjects:
Agrochemicals
Atom economy
Chemical bonds
Chemical reactions
Chemistry
Coupling (molecular)
Cross coupling
Functional groups
Functional materials
Heterocyclic compounds
Hydrogen bonds
Natural products
Oxidants
Oxidizing agents
Oxygen
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Summary:Aerobic oxidative cross-coupling represents one of the most straightforward and atom-economic methods for construction of C-C and C-X (X=N, O, S, or P) bonds using air as a sustainable external oxidant. The oxidative coupling of C-H bonds in heterocyclic compounds can effectively increase their molecular complexity by introducing new functional groups through C-H bond activation, or by formation of new heterocyclic structures through cascade construction of two or more sequential chemical bonds. This is very useful as it can increase the potential applications of these structures in natural products, pharmaceuticals, agricultural chemicals, and functional materials. This is a representative overview of recent progress since 2010 on green oxidative coupling reactions of C-H bond using O or air as internal oxidant focus on Heterocycles. It aims to provide a platform for expanding the scope and utility of air as green oxidant, together with a brief discussion on research into the mechanisms behind it.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202301700