Lower serum zinc level is associated with higher fasting insulin in type 2 diabetes mellitus (T2DM) and relates with disturbed glucagon suppression response in male patients

Zinc ion can play critical role in glycemic control in diabetes mellitus (DM), contributing to both insulin synthesis and secretion. In this study, we aimed to investigate the level of zinc in diabetic patients and its association with glycemic parameters, insulin, and glucagon level. Methods: 112 i...

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Bibliographic Details
Published in:Primary care diabetes 2023-10, Vol.17 (5), p.493-498
Main Authors: Safarzad, Mahdieh, Jazi, Marie Saghaeian, Kiaei, Mohammadreza, Asadi, Jahanbakhsh
Format: Article
Language:English
Subjects:
Blood Glucose
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - drug therapy
Fasting
Female
Glucagon
Glycated Hemoglobin
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Male
Type 2 diabetes mellitus
Zinc
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Summary:Zinc ion can play critical role in glycemic control in diabetes mellitus (DM), contributing to both insulin synthesis and secretion. In this study, we aimed to investigate the level of zinc in diabetic patients and its association with glycemic parameters, insulin, and glucagon level. Methods: 112 individuals (59 cases of type 2DM and 53 non-diabetic controls) were included in this study. Biochemical parameters (FBG, 2hpp, HbA1C), and zinc level in the serum were measured using colorimetric assays. Insulin and glucagon were measured by ELISA method. HOMA-IR, HOMA-B, reciprocal HOMA-B, and Quicki indices were calculated using appropriate formula. For further analysis, patients were divided into two groups: high (>135.5 μg/dl) and low (
ISSN:1751-9918
1878-0210
DOI:10.1016/j.pcd.2023.05.008