Polyisobutylene-based biomaterials

• Published in: Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2004-07, Vol.42 (13), p.3091-3109
• Main Authors: Puskas, Judit E., Chen, Yaohong, Dahman, Yaser, Padavan, Donna
• Format: Article
• Language: English
• Subjects: Applied sciences; biocompatibility; biomaterials; Exact sciences and technology; living carbocationic polymerization; Organic polymers; Physicochemistry of polymers; polyisobutylene; Polymerization; Preparation, kinetics, thermodynamics, mechanism and catalysts; surface modification; surfaces
• ISSN: 0887-624X; 1099-0518
• DOI: 10.1002/pola.20114

This article highlights the biomaterial‐related research of the Macromolecular Engineering Research Centre (MERC). The MERC group concentrated on polyisobutylene (PIB)‐based biomaterials. In this article, first the unique properties of PIB are discussed, followed by a review of PIB‐based potential biomaterials. MERC's systematic research program aimed to develop novel PIB‐based biomaterials is then highlighted, including surface modification and biocompatibility studies. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 3091–3109, 2004 Polyisobutylene's (PIB) unique combination of properties renders PIB‐based polymers potential new biomaterials. This highlight article discusses the unique characteristics of PIB, followed by a review of PIB‐based potential biomaterials. PIB–polystyrene block copolymers are prepared by living carbocationic polymerization. They are bridging the property range between polyurethanes and silicone rubber, with superior barrier properties and biocompatibility demonstrated in vitro and in vivo. Examples of potential applications include breast implants, vascular grafts, and medicated coronary stents. This article also discusses our latest results related to PIB‐based biomaterials, including surface modification for improved biocompatibility.