Organic-inorganic hybrids of collagen or biodegradable polymers with hydroxyapatite

In this research we utilize three polymers, including collagen, diblock PEG-PLGA copolymer and triblock PEG-PLGA-PEG copolymer for biomimetic hydroxyapatite (HAp) preparation. Average crystallite sizes of precipitated HAp from polymer solutions were estimated from XRD patterns to be ca. 23 nm for th...

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Bibliographic Details
Published in:Key engineering materials 2004-01, Vol.254-256, p.473-476
Main Authors: Hsieh, M F, Chung, R J, Hsu, T J, Perng, L H, Chin, T S
Format: Article
Language:English
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Summary:In this research we utilize three polymers, including collagen, diblock PEG-PLGA copolymer and triblock PEG-PLGA-PEG copolymer for biomimetic hydroxyapatite (HAp) preparation. Average crystallite sizes of precipitated HAp from polymer solutions were estimated from XRD patterns to be ca. 23 nm for those in collagen-HAp hybrids and 30 nm for those without polymer addition. Scanning electron micrographs showed that the organic macromolecules induced HAp with regular plate-like shape and nano-sized structure. Thermogravimetric analyses showed 2-3 wt% polymer content in the hybrids. Solid state NMR revealed polymer incorporation in HAp crystal. The hybrids containing these biodegradable polymers can be processed to various morphologies for tissue engineering applications.
ISSN:1013-9826