The emerging role of microRNA-126 as a potential therapeutic target in cancer: a comprehensive review

• Published in: Pathology, research and practice research and practice, 2023-08, Vol.248, p.154631-154631, Article 154631
• Main Authors: Jalil, Abduladheem Turki, Abdulhadi, Mohanad Ali, Al-Ameer, Lubna R., Abbas, Hussein Abdullah, Merza, Muna.S., Zabibah, Rahman S., Fadhil, Ali A.
• Format: Article
• Language: English
• Subjects: Cancer; Malignancy; MicroRNA-126; Therapy
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2023.154631

MicroRNA-126 (miR-126) has become a key player in the biology of cancer, playing a variety of functions in carcinogenesis and cancer development. The diagnostic and prognostic potential of miR-126 in diverse cancer types is summarized in this thorough analysis, with an emphasis on its role in tumor angiogenesis, invasion, metastasis, cell proliferation, apoptosis, and treatment resistance. MiR-126 dysregulation is linked to a higher risk of developing cancer and a worse prognosis. Notably, miR-126 affects tumor vascularization and development by targeting vascular endothelial growth factor-A (VEGF-A). Through its impact on genes involved in cell adhesion and migration, it also plays a vital part in cancer cell invasion and metastasis. Additionally, miR-126 controls drug resistance, apoptosis, and cell proliferation, which affects cancer cell survival and treatment response. It may be possible to develop innovative therapeutic approaches to stop tumor angiogenesis, invasion, and metastasis, as well as combat drug resistance by focusing on miR-126 or its downstream effectors. The versatility of miR-126's functions highlights the role that it plays in cancer biology. To understand the processes behind miR-126 dysregulation, pinpoint precise targets, and create efficient therapies, more investigation is required. Utilizing miR-126's therapeutic potential might have a significant influence on cancer treatment plans and patient outcomes.