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Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy
Tamoxifen (TAM) is often recommended as a first-line treatment for estrogen receptor-positive breast cancer (BC). However, TAM resistance continues to be a medical challenge for BC with hormone receptor positivity. The function of macro-autophagy and autophagy has recently been identified to be alte...
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| Published in: | Fundamental & clinical pharmacology 2023-12, Vol.37 (6), p.1092-1108 |
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| Main Authors: | , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c313t-53abd52af97ea8efce217dcaa2fa356fcbcedd59594c18b28455dfd808f8b2b73 |
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| cites | cdi_FETCH-LOGICAL-c313t-53abd52af97ea8efce217dcaa2fa356fcbcedd59594c18b28455dfd808f8b2b73 |
| container_end_page | 1108 |
| container_issue | 6 |
| container_start_page | 1092 |
| container_title | Fundamental & clinical pharmacology |
| container_volume | 37 |
| creator | Zamanian, Mohammad Yasin Golmohammadi, Maryam Nili-Ahmadabadi, Amir Alameri, Ameer A Al-Hassan, Mohammed Alshahrani, Shadia Hamoud Hasan, Mohammed Sami Ramírez-Coronel, Andrés Alexis Qasim, Qutaiba A Heidari, Mahsa Verma, Amita |
| description | Tamoxifen (TAM) is often recommended as a first-line treatment for estrogen receptor-positive breast cancer (BC). However, TAM resistance continues to be a medical challenge for BC with hormone receptor positivity. The function of macro-autophagy and autophagy has recently been identified to be altered in BC, which suggests a potential mechanism for TAM resistance. Autophagy is a cellular stress-induced response to preserve cellular homeostasis. Also, therapy-induced autophagy, which is typically cytoprotective and activated in tumor cells, could sometimes be non-protective, cytostatic, or cytotoxic depending on how it is regulated.
This review explored the literature on the connections between hormonal therapies and autophagy. We investigated how autophagy could develop drug resistance in BC cells.
Scopus, Science Direct, PubMed, and Google Scholar were used to search articles for this study.
The results demonstrated that protein kinases such as pAMPK, BAX, and p-p70S6K could be a sign of autophagy in developing TAM resistance. According to the study's findings, autophagy plays an important role in BC patients' TAM resistance.
Therefore, by overcoming endocrine resistance in estrogen receptor-positive breast tumors, autophagy inhibition may improve the therapeutic efficacy of TAM. |
| doi_str_mv | 10.1111/fcp.12936 |
| format | article |
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This review explored the literature on the connections between hormonal therapies and autophagy. We investigated how autophagy could develop drug resistance in BC cells.
Scopus, Science Direct, PubMed, and Google Scholar were used to search articles for this study.
The results demonstrated that protein kinases such as pAMPK, BAX, and p-p70S6K could be a sign of autophagy in developing TAM resistance. According to the study's findings, autophagy plays an important role in BC patients' TAM resistance.
Therefore, by overcoming endocrine resistance in estrogen receptor-positive breast tumors, autophagy inhibition may improve the therapeutic efficacy of TAM.</description><identifier>ISSN: 0767-3981</identifier><identifier>EISSN: 1472-8206</identifier><identifier>DOI: 10.1111/fcp.12936</identifier><identifier>PMID: 37402635</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Autophagy ; Breast cancer ; Cytotoxicity ; Drug resistance ; Estrogen receptors ; Estrogens ; Homeostasis ; Kinases ; Literature reviews ; Molecular modelling ; Pharmacology ; Receptors ; Search engines ; Tamoxifen ; Tumor cells ; Tumors</subject><ispartof>Fundamental & clinical pharmacology, 2023-12, Vol.37 (6), p.1092-1108</ispartof><rights>2023 Société Française de Pharmacologie et de Thérapeutique.</rights><rights>2023 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-53abd52af97ea8efce217dcaa2fa356fcbcedd59594c18b28455dfd808f8b2b73</citedby><cites>FETCH-LOGICAL-c313t-53abd52af97ea8efce217dcaa2fa356fcbcedd59594c18b28455dfd808f8b2b73</cites><orcidid>0000-0003-0944-0320</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37402635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zamanian, Mohammad Yasin</creatorcontrib><creatorcontrib>Golmohammadi, Maryam</creatorcontrib><creatorcontrib>Nili-Ahmadabadi, Amir</creatorcontrib><creatorcontrib>Alameri, Ameer A</creatorcontrib><creatorcontrib>Al-Hassan, Mohammed</creatorcontrib><creatorcontrib>Alshahrani, Shadia Hamoud</creatorcontrib><creatorcontrib>Hasan, Mohammed Sami</creatorcontrib><creatorcontrib>Ramírez-Coronel, Andrés Alexis</creatorcontrib><creatorcontrib>Qasim, Qutaiba A</creatorcontrib><creatorcontrib>Heidari, Mahsa</creatorcontrib><creatorcontrib>Verma, Amita</creatorcontrib><title>Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy</title><title>Fundamental & clinical pharmacology</title><addtitle>Fundam Clin Pharmacol</addtitle><description>Tamoxifen (TAM) is often recommended as a first-line treatment for estrogen receptor-positive breast cancer (BC). However, TAM resistance continues to be a medical challenge for BC with hormone receptor positivity. The function of macro-autophagy and autophagy has recently been identified to be altered in BC, which suggests a potential mechanism for TAM resistance. Autophagy is a cellular stress-induced response to preserve cellular homeostasis. Also, therapy-induced autophagy, which is typically cytoprotective and activated in tumor cells, could sometimes be non-protective, cytostatic, or cytotoxic depending on how it is regulated.
This review explored the literature on the connections between hormonal therapies and autophagy. We investigated how autophagy could develop drug resistance in BC cells.
Scopus, Science Direct, PubMed, and Google Scholar were used to search articles for this study.
The results demonstrated that protein kinases such as pAMPK, BAX, and p-p70S6K could be a sign of autophagy in developing TAM resistance. According to the study's findings, autophagy plays an important role in BC patients' TAM resistance.
Therefore, by overcoming endocrine resistance in estrogen receptor-positive breast tumors, autophagy inhibition may improve the therapeutic efficacy of TAM.</description><subject>Autophagy</subject><subject>Breast cancer</subject><subject>Cytotoxicity</subject><subject>Drug resistance</subject><subject>Estrogen receptors</subject><subject>Estrogens</subject><subject>Homeostasis</subject><subject>Kinases</subject><subject>Literature reviews</subject><subject>Molecular modelling</subject><subject>Pharmacology</subject><subject>Receptors</subject><subject>Search engines</subject><subject>Tamoxifen</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>0767-3981</issn><issn>1472-8206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkMtO5DAQRa0Ro6FpWPADyBIbWITxI7Eddqg1PCSk2fSso4pT7g5K4mA7gv570sNjQW1KJZ17VTqEnHJ2xef57ex4xUUp1Q-y4LkWmRFMHZAF00pnsjT8kBzF-MQY14yrX-RQ6pwJJYsFqdcQNpjaYUNhSn7cwmZHX9q0pQl6_9o6HGg70DogxEQtDBbDNb0Nvqe979BOHQTao93C0MY-0uTn4L4RG5q2GGDcHZOfDrqIJx97Sf7d_lmv7rPHv3cPq5vHzEouU1ZIqJtCgCs1gkFnUXDdWADhQBbK2dpi0xRlUeaWm1qYvCga1xhm3HzVWi7JxXvvGPzzhDFVfRstdh0M6KdYCSOlypWaRS3J-Tf0yU9hmL-bqVKWWhi2py7fKRt8jAFdNYa2h7CrOKv24qtZfPVf_MyefTROdY_NF_lpWr4B-d5_8A</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Zamanian, Mohammad Yasin</creator><creator>Golmohammadi, Maryam</creator><creator>Nili-Ahmadabadi, Amir</creator><creator>Alameri, Ameer A</creator><creator>Al-Hassan, Mohammed</creator><creator>Alshahrani, Shadia Hamoud</creator><creator>Hasan, Mohammed Sami</creator><creator>Ramírez-Coronel, Andrés Alexis</creator><creator>Qasim, Qutaiba A</creator><creator>Heidari, Mahsa</creator><creator>Verma, Amita</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0944-0320</orcidid></search><sort><creationdate>20231201</creationdate><title>Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy</title><author>Zamanian, Mohammad Yasin ; Golmohammadi, Maryam ; Nili-Ahmadabadi, Amir ; Alameri, Ameer A ; Al-Hassan, Mohammed ; Alshahrani, Shadia Hamoud ; Hasan, Mohammed Sami ; Ramírez-Coronel, Andrés Alexis ; Qasim, Qutaiba A ; Heidari, Mahsa ; Verma, Amita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-53abd52af97ea8efce217dcaa2fa356fcbcedd59594c18b28455dfd808f8b2b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autophagy</topic><topic>Breast cancer</topic><topic>Cytotoxicity</topic><topic>Drug resistance</topic><topic>Estrogen receptors</topic><topic>Estrogens</topic><topic>Homeostasis</topic><topic>Kinases</topic><topic>Literature reviews</topic><topic>Molecular modelling</topic><topic>Pharmacology</topic><topic>Receptors</topic><topic>Search engines</topic><topic>Tamoxifen</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zamanian, Mohammad Yasin</creatorcontrib><creatorcontrib>Golmohammadi, Maryam</creatorcontrib><creatorcontrib>Nili-Ahmadabadi, Amir</creatorcontrib><creatorcontrib>Alameri, Ameer A</creatorcontrib><creatorcontrib>Al-Hassan, Mohammed</creatorcontrib><creatorcontrib>Alshahrani, Shadia Hamoud</creatorcontrib><creatorcontrib>Hasan, Mohammed Sami</creatorcontrib><creatorcontrib>Ramírez-Coronel, Andrés Alexis</creatorcontrib><creatorcontrib>Qasim, Qutaiba A</creatorcontrib><creatorcontrib>Heidari, Mahsa</creatorcontrib><creatorcontrib>Verma, Amita</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Fundamental & clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zamanian, Mohammad Yasin</au><au>Golmohammadi, Maryam</au><au>Nili-Ahmadabadi, Amir</au><au>Alameri, Ameer A</au><au>Al-Hassan, Mohammed</au><au>Alshahrani, Shadia Hamoud</au><au>Hasan, Mohammed Sami</au><au>Ramírez-Coronel, Andrés Alexis</au><au>Qasim, Qutaiba A</au><au>Heidari, Mahsa</au><au>Verma, Amita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy</atitle><jtitle>Fundamental & clinical pharmacology</jtitle><addtitle>Fundam Clin Pharmacol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>37</volume><issue>6</issue><spage>1092</spage><epage>1108</epage><pages>1092-1108</pages><issn>0767-3981</issn><eissn>1472-8206</eissn><abstract>Tamoxifen (TAM) is often recommended as a first-line treatment for estrogen receptor-positive breast cancer (BC). However, TAM resistance continues to be a medical challenge for BC with hormone receptor positivity. The function of macro-autophagy and autophagy has recently been identified to be altered in BC, which suggests a potential mechanism for TAM resistance. Autophagy is a cellular stress-induced response to preserve cellular homeostasis. Also, therapy-induced autophagy, which is typically cytoprotective and activated in tumor cells, could sometimes be non-protective, cytostatic, or cytotoxic depending on how it is regulated.
This review explored the literature on the connections between hormonal therapies and autophagy. We investigated how autophagy could develop drug resistance in BC cells.
Scopus, Science Direct, PubMed, and Google Scholar were used to search articles for this study.
The results demonstrated that protein kinases such as pAMPK, BAX, and p-p70S6K could be a sign of autophagy in developing TAM resistance. According to the study's findings, autophagy plays an important role in BC patients' TAM resistance.
Therefore, by overcoming endocrine resistance in estrogen receptor-positive breast tumors, autophagy inhibition may improve the therapeutic efficacy of TAM.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37402635</pmid><doi>10.1111/fcp.12936</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-0944-0320</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0767-3981 |
| ispartof | Fundamental & clinical pharmacology, 2023-12, Vol.37 (6), p.1092-1108 |
| issn | 0767-3981 1472-8206 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2833646629 |
| source | Wiley |
| subjects | Autophagy Breast cancer Cytotoxicity Drug resistance Estrogen receptors Estrogens Homeostasis Kinases Literature reviews Molecular modelling Pharmacology Receptors Search engines Tamoxifen Tumor cells Tumors |
| title | Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy |
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