Decreased Risk of Preeclampsia in Women with Inflammatory Bowel Disease on Anti-Tumor Necrosis Factor Therapy

Background Evidence suggests that upregulation of tumor necrosis factor-alpha (TNF-α) plays a role in immune dysregulation in both preeclampsia and inflammatory bowel disease (IBD). Aims We aimed to investigate whether anti-TNF therapy during pregnancy decreases the risk of preeclampsia in women wit...

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Bibliographic Details
Published in:Digestive diseases and sciences 2023-09, Vol.68 (9), p.3557-3561
Main Authors: Patel, Nisha B., Vinsard, Daniela Guerrero, Kattah, Andrea G., Kane, Sunanda V.
Format: Article
Language:English
Subjects:
Adalimumab
Biochemistry
Brief Report
Comparative analysis
Gastroenterology
Gastrointestinal diseases
Hepatology
Inflammatory bowel disease
Medicine
Medicine & Public Health
Necrosis
Oncology
Preeclampsia
Pregnancy
Risk factors
Transplant Surgery
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumors
Women
Womens health
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Summary:Background Evidence suggests that upregulation of tumor necrosis factor-alpha (TNF-α) plays a role in immune dysregulation in both preeclampsia and inflammatory bowel disease (IBD). Aims We aimed to investigate whether anti-TNF therapy during pregnancy decreases the risk of preeclampsia in women with IBD. Methods The study population included women with IBD and pregnancies who were followed at a tertiary care center from 2007 to 2021. Cases of preeclampsia were compared with controls with a normotensive pregnancy. Data on patient demographics, disease type and activity, pregnancy complications, and additional risk factors for preeclampsia were collected. The association between anti-TNF therapy and preeclampsia was analyzed using univariate analysis and multivariate logistic regression. Results Women with preeclampsia were more likely to have a preterm delivery (44% vs. 12%, p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-023-08016-x